filipin III
CHEBI:83267 EXACT SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A macrolide that is the major component of a mixture of four isomeric polyene macrolides isolated from Streptomyces filipinensis.
Structure
| Standard InChIKey | IMQSIXYSKPIGPD-YQRUMEKGSA-N |
|---|---|
| SMILES | CCCCC[C@@H](O)[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)\C(C)=C\C=C\C=C\C=C\C=C\[C@H](O)[C@@H](C)OC1=O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:25439, npatlas:NPA032748, pubchem:6433194 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces lavendulae strain YAKB-15 NCBITaxon:1914 |
BGC_CORRELATED | mibig:BGC0002789 | DOI:10.1007/s00253-023-12672-4 |
| Streptomyces avermitilis MA-4680 = NBRC 14893 NCBITaxon:227882 |
SOURCE_ASSERTION | mibig:BGC0000059 | PMID:23990133 |
Occurrences 13
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces miharaensis NCBITaxon:285483 |
LOTUS | DOI:10.1002/JOBM.201100134 |
| Streptomyces avermitilis NCBITaxon:33903 |
LOTUS | DOI:10.1007/S10295-013-1327-X |
| Streptomyces avermitilis NCBITaxon:33903 |
LOTUS | DOI:10.1016/J.JBIOSC.2017.06.014 |
| Streptomyces avermitilis NCBITaxon:33903 |
LOTUS | DOI:10.1074/JBC.M109.092460 |
| Streptomyces avermitilis NCBITaxon:33903 |
LOTUS | DOI:10.1099/MIC.0.048371-0 |
| Streptomyces avermitilis NCBITaxon:33903 |
LOTUS | DOI:10.1111/J.1574-6968.2009.01721.X |
| Streptomyces avermitilis NCBITaxon:33903 |
LOTUS | DOI:10.1128/AEM.02843-13 |
| Streptomyces eurythermus NCBITaxon:42237 |
LOTUS | DOI:10.1038/JA.2015.76 |
| Streptomyces filipinensis NCBITaxon:66887 |
LOTUS | DOI:10.1186/S12934-015-0307-4 |
| Streptomyces filipinensis NCBITaxon:66887 |
LOTUS | DOI:10.7164/ANTIBIOTICS.23.414 |
| Streptomyces filipinensis NCBITaxon:66887 |
LOTUS | DOI:10.7164/ANTIBIOTICS.38.485 |
| Streptomyces filipinensis NCBITaxon:66887 |
CHEBI | PMID:5453318 |
| Streptomyces lavenduligriseus NCBITaxon:67315 |
LOTUS | DOI:10.1038/JA.2015.76 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002789 | Streptomyces lavendulae strain YAKB-15 NCBITaxon:1914 |
CLUSTER_CORRELATED | genbank:SMSN01000006.1 |
| mibig:BGC0000059 | Streptomyces avermitilis MA-4680 = NBRC 14893 NCBITaxon:227882 |
CLUSTER_UNSTATED | genbank:BA000030.3 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000059, BGC0002789. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002789 | MIBIG | 2 |
| BGC0000059 | MIBIG | 5 |
| CHEBI:83267 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/filipin-iii.yaml, which is generated from the committed inventories. Neither is edited by hand.