fredericamycin A
naturalproductmech:mibig-d37598ecc7 MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | BZONSJUONOFNNP-MHSJTTIKSA-N |
|---|---|
| SMILES | COC1=CC(=O)C2=C(C(O)=C3C(=O)[C@]4(CCC5=CC6=C(C(=O)NC(\C=C\C=C\C)=C6)C(O)=C45)C(=O)C3=C2O)C1=O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA016501, pubchem:5384075 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces griseus NCBITaxon:1911 |
BGC_CHARACTERIZED | mibig:BGC0000224 | PMID:16305230 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces griseus NCBITaxon:1911 |
LOTUS | DOI:10.1007/S00253-009-2428-3 |
| Streptomyces griseus NCBITaxon:1911 |
LOTUS | DOI:10.1021/JA054376U |
| Streptomyces griseus NCBITaxon:1911 |
LOTUS | DOI:10.1021/NP070664N |
| Streptomyces griseus NCBITaxon:1911 |
LOTUS | DOI:10.1074/JBC.M110.147744 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000224 | Streptomyces griseus NCBITaxon:1911 |
CLUSTER_DEMONSTRATED | genbank:AF525490.2 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000224 | MIBIG | 4 |
This page is generated from data/natural_products/polyketides/fredericamycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.