fusarubin

naturalproductmech:mibig-e1b611846e MINTED SEEDED cytotoxic

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	FKJXMYJPOKQPSS-UHFFFAOYSA-N
SMILES	CC1(CC2=C(CO1)C(=C3C(=O)C=C(C(=O)C3=C2O)OC)O)O
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	pubchem:73421, npatlas:NPA0830

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 2

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Fusarium sp. NCBITaxon:29916	BGC_CHARACTERIZED	mibig:BGC0002525	PMID:32139880
Fusarium fujikuroi NCBITaxon:5127	SOURCE_ASSERTION	mibig:BGC0001242	PMID:22492438

Occurrences 7

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Fusarium solani NCBITaxon:169388	LOTUS	DOI:10.1016/0031-9422(89)80318-8
Fusarium solani NCBITaxon:169388	LOTUS	DOI:10.1039/JR9470001021
Fusarium solani NCBITaxon:169388	LOTUS	DOI:10.1139/V78-260
Fusarium solani NCBITaxon:169388	LOTUS	DOI:10.7164/ANTIBIOTICS.39.205
Fusarium NCBITaxon:5506	LOTUS	DOI:10.1021/NP100282K
Fusarium haematococcum NCBITaxon:984957	LOTUS	DOI:10.1016/0031-9422(89)80318-8
Fusarium fujikuroi NCBITaxon:5127	LOTUS	DOI:10.1128/AEM.00823-12

Biosynthetic gene clusters 2

Accession	Host	Locus evidence	Genome
mibig:BGC0002525	Fusarium sp. NCBITaxon:29916	CLUSTER_DEMONSTRATED	genbank:LC516401.1
mibig:BGC0001242	Fusarium fujikuroi NCBITaxon:5127	CLUSTER_UNSTATED	genbank:HE613440.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 25

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Explore across X-Mech

AntibioticMech (fusarubin) ↗ MediaIngredientMech (naturalproductmech:mibig-e1b611846e) ↗ TaxonMech: Fusarium sp. (NCBITaxon:29916) ↗ TaxonMech: Fusarium fujikuroi (NCBITaxon:5127) ↗ PathwayMech (mibig:BGC0002525) ↗ PathwayMech (mibig:BGC0001242) ↗

Open questions 1

shared-structure — This structure is reported by more than one MIBiG entry: BGC0001242, BGC0002525. Confirm they describe the same compound rather than an upstream cross-reference error.

Provenance

Source concept	Source	Version
BGC0002525	MIBIG	3
BGC0001242	MIBIG	3

This page is generated from data/natural_products/polyketides/fusarubin.yaml, which is generated from the committed inventories. Neither is edited by hand.

Assay	Result	Target enzyme	Source detail
NCI Yeast Anticancer Drug Screen. Data for the bub3 strain	ACTIVE	Not recorded	pubchem.aid:167 assay NCI Yeast Anticancer Drug Screen. Data for the bub3 strain evidence reference pubchem.aid:167 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 167, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain	ACTIVE	Not recorded	pubchem.aid:157 assay NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain evidence reference pubchem.aid:157 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 157, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain	ACTIVE	Not recorded	pubchem.aid:175 assay NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain evidence reference pubchem.aid:175 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 175, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the rad50 strain	ACTIVE	Not recorded	pubchem.aid:155 assay NCI Yeast Anticancer Drug Screen. Data for the rad50 strain evidence reference pubchem.aid:155 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 155, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain	ACTIVE	Not recorded	pubchem.aid:161 assay NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain evidence reference pubchem.aid:161 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 161, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794740 assay NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794740 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794740, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794742 assay NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794742 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794742, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794799 assay NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794799 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794799, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794798 assay NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794798 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794798, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794746 assay NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794746 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794746, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794776 assay NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794776 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794776, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794735 assay NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794735 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794735, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794738 assay NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794738 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794738, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the HT29 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794748 assay NCI human tumor cell line growth inhibition assay. Data for the HT29 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794748 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794748, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the KM12 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794800 assay NCI human tumor cell line growth inhibition assay. Data for the KM12 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794800 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794800, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the M14 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794745 assay NCI human tumor cell line growth inhibition assay. Data for the M14 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794745 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794745, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794766 assay NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794766 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794766, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794796 assay NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794796 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794796, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Melanoma cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794794 assay NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Melanoma cell line, single concentration evidence reference pubchem.aid:1794794 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794794, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794731 assay NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794731 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794731, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794733 assay NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794733 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794733, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794736 assay NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794736 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794736, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Ovarian cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794790 assay NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Ovarian cell line, single concentration evidence reference pubchem.aid:1794790 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794790, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794787 assay NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794787 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794787, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794784 assay NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794784 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794784, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC notes 9 further PubChem assay results are in data/raw/pubchem_bioassay.tsv but not written here.