fusarubin
naturalproductmech:mibig-e1b611846e MINTED SEEDED cytotoxic
Structure
| Standard InChIKey | FKJXMYJPOKQPSS-UHFFFAOYSA-N |
|---|---|
| SMILES | CC1(CC2=C(CO1)C(=C3C(=O)C=C(C(=O)C3=C2O)OC)O)O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:73421, npatlas:NPA0830 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Fusarium sp. NCBITaxon:29916 |
BGC_CHARACTERIZED | mibig:BGC0002525 | PMID:32139880 |
| Fusarium fujikuroi NCBITaxon:5127 |
SOURCE_ASSERTION | mibig:BGC0001242 | PMID:22492438 |
Occurrences 7
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Fusarium solani NCBITaxon:169388 |
LOTUS | DOI:10.1016/0031-9422(89)80318-8 |
| Fusarium solani NCBITaxon:169388 |
LOTUS | DOI:10.1039/JR9470001021 |
| Fusarium solani NCBITaxon:169388 |
LOTUS | DOI:10.1139/V78-260 |
| Fusarium solani NCBITaxon:169388 |
LOTUS | DOI:10.7164/ANTIBIOTICS.39.205 |
| Fusarium NCBITaxon:5506 |
LOTUS | DOI:10.1021/NP100282K |
| Fusarium haematococcum NCBITaxon:984957 |
LOTUS | DOI:10.1016/0031-9422(89)80318-8 |
| Fusarium fujikuroi NCBITaxon:5127 |
LOTUS | DOI:10.1128/AEM.00823-12 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002525 | Fusarium sp. NCBITaxon:29916 |
CLUSTER_DEMONSTRATED | genbank:LC516401.1 |
| mibig:BGC0001242 | Fusarium fujikuroi NCBITaxon:5127 |
CLUSTER_UNSTATED | genbank:HE613440.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 25
| Assay | Result | Reference |
|---|---|---|
| NCI Yeast Anticancer Drug Screen. Data for the bub3 strain | ACTIVE | pubchem.aid:167 |
| NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain | ACTIVE | pubchem.aid:157 |
| NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain | ACTIVE | pubchem.aid:175 |
| NCI Yeast Anticancer Drug Screen. Data for the rad50 strain | ACTIVE | pubchem.aid:155 |
| NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain | ACTIVE | pubchem.aid:161 |
| NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794740 |
| NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794742 |
| NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794799 |
| NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794798 |
| NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794746 |
| NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794776 |
| NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794735 |
| NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794738 |
| NCI human tumor cell line growth inhibition assay. Data for the HT29 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794748 |
| NCI human tumor cell line growth inhibition assay. Data for the KM12 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794800 |
| NCI human tumor cell line growth inhibition assay. Data for the M14 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794745 |
| NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794766 |
| NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794796 |
| NCI human tumor cell line growth inhibition assay. Data for the MDA-MB-435 Melanoma cell line, single concentration | ACTIVE | pubchem.aid:1794794 |
| NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794731 |
| NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794733 |
| NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794736 |
| NCI human tumor cell line growth inhibition assay. Data for the NCI/ADR-RES Ovarian cell line, single concentration | ACTIVE | pubchem.aid:1794790 |
| NCI human tumor cell line growth inhibition assay. Data for the OVCAR-3 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794787 |
| NCI human tumor cell line growth inhibition assay. Data for the OVCAR-4 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794784 |
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0001242, BGC0002525. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002525 | MIBIG | 3 |
| BGC0001242 | MIBIG | 3 |
This page is generated from data/natural_products/polyketides/fusarubin.yaml, which is generated from the committed inventories. Neither is edited by hand.