herboxidiene
naturalproductmech:mibig-2d09306d15 MINTED SEEDED cytotoxicenzyme inhibitor
Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | ISZXEMUWHQLLTC-GZSUCXPKSA-N |
|---|---|
| SMILES | COC(C(C)O)C(C)C1OC1(C)CC(C)\C=C\C=C(/C)[C@@H]1OC(CC(O)=O)CC[C@H]1C |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA06425, pubchem:6438496 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces chromofuscus NCBITaxon:42881 |
SOURCE_ASSERTION | mibig:BGC0001065 | PMID:22247174 |
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001065 | Streptomyces chromofuscus NCBITaxon:42881 |
CLUSTER_UNSTATED | genbank:JN671974.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Bioactivities 19
Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.
| Assay | Result | Target enzyme | Source detail |
|---|---|---|---|
| A2780 Cisplatin Sensitive Ovarian Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| G06 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| HEK-293 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| HPAF-II Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| J3T Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| KB-3-1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| KB-8-5-11 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| MCF7 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| Panc-1005 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| SDT Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| UWB1.289 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| Viability qHTS for inhibitors of the SERCaMP assay screened against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| qHTS for ATAD5 Agonist screened against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| qHTS for Activators of p53 Stress Response Pathway screened against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| qHTS for Activators of p53 Stress Response Pathway screened against the NCATS CANVASS Library | ACTIVE | UniProtKB:P04637 | PMID:30648156
|
| qHTS for Antimalaria activity screened against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| qHTS for Constitutive Androstane Receptor (CAR) Agonist screened against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| qHTS for Inflammasome Signaling Inhibitors: IL-1-beta AlphaLISA screen against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
| qHTS for activators of Nrf2/ARE signaling pathway screened against the NCATS CANVASS Library | ACTIVE | Not recorded | PMID:30648156
|
Explore across X-Mech
AntibioticMech (herboxidiene) ↗
MediaIngredientMech (naturalproductmech:mibig-2d09306d15) ↗
TaxonMech: Streptomyces chromofuscus (NCBITaxon:42881) ↗
PathwayMech (mibig:BGC0001065) ↗
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001065 | MIBIG | 5 |
This page is generated from data/natural_products/polyketides/herboxidiene.yaml, which is generated from the committed inventories. Neither is edited by hand.