NaturalProductMech

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hypothemycin

naturalproductmech:mibig-6d77987130 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyHDZUUVQEDFZKAX-JOLUUEAESA-N
SMILESCC1C/C=C\C(=O)C2C(O2)CC([C@H](C3=CC(=CC(=C3C(=O)O1)O)OC)O)O
Stereochemistry undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-referencespubchem:6474405

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 2

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Hypomyces subiculosus
NCBITaxon:193393		 SOURCE_ASSERTION mibig:BGC0000076 DOI:10.7554/elife.00712
Hypomyces subiculosus
NCBITaxon:193393		 SOURCE_ASSERTION mibig:BGC0000077 PMID:18567690

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Hypomyces subiculosus
NCBITaxon:193393		 LOTUS DOI:10.1128/AEM.00478-08

Biosynthetic gene clusters 2

AccessionHostLocus evidenceGenome
mibig:BGC0000076 Hypomyces subiculosus
NCBITaxon:193393 		CLUSTER_UNSTATED genbank:EU520417.1
mibig:BGC0000077 Hypomyces subiculosus
NCBITaxon:193393 		CLUSTER_UNSTATED genbank:EU520418.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 2 producers (0 causal) 1 cited occurrence BIOSYNTHETIC LOCUS 2 gene clusters 0 curated pathway steps NATURAL PRODUCT hypothemycin naturalproductmech:mibig-6d77987130 Polyketides TARGETS & BIOACTIVITY 0 molecular targets 0 bioactivities · 0 graphs

Explore across X-Mech

AntibioticMech (hypothemycin) ↗ MediaIngredientMech (naturalproductmech:mibig-6d77987130) ↗ TaxonMech: Hypomyces subiculosus (NCBITaxon:193393) ↗ TaxonMech: Hypomyces subiculosus (NCBITaxon:193393) ↗ PathwayMech (mibig:BGC0000076) ↗ PathwayMech (mibig:BGC0000077) ↗

Open questions 1

shared-structure — This structure is reported by more than one MIBiG entry: BGC0000076, BGC0000077. Confirm they describe the same compound rather than an upstream cross-reference error.

Provenance

Source conceptSourceVersion
BGC0000076MIBIG3
BGC0000077MIBIG3

This page is generated from data/natural_products/polyketides/hypothemycin.yaml, which is generated from the committed inventories. Neither is edited by hand.