hypothemycin
naturalproductmech:mibig-6d77987130 MINTED SEEDED
Structure
| Standard InChIKey | HDZUUVQEDFZKAX-JOLUUEAESA-N |
|---|---|
| SMILES | CC1C/C=C\C(=O)C2C(O2)CC([C@H](C3=CC(=CC(=C3C(=O)O1)O)OC)O)O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:6474405 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Hypomyces subiculosus NCBITaxon:193393 |
SOURCE_ASSERTION | mibig:BGC0000076 | DOI:10.7554/elife.00712 |
| Hypomyces subiculosus NCBITaxon:193393 |
SOURCE_ASSERTION | mibig:BGC0000077 | PMID:18567690 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Hypomyces subiculosus NCBITaxon:193393 |
LOTUS | DOI:10.1128/AEM.00478-08 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000076 | Hypomyces subiculosus NCBITaxon:193393 |
CLUSTER_UNSTATED | genbank:EU520417.1 |
| mibig:BGC0000077 | Hypomyces subiculosus NCBITaxon:193393 |
CLUSTER_UNSTATED | genbank:EU520418.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000076, BGC0000077. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000076 | MIBIG | 3 |
| BGC0000077 | MIBIG | 3 |
This page is generated from data/natural_products/polyketides/hypothemycin.yaml, which is generated from the committed inventories. Neither is edited by hand.