komodoquinone B
CHEBI:167002 EXACT SEEDED
A member of the class of tetracenequinones that is 7,8,9,10-tetrahydrotetracene-5,12-dione carrying hydroxy groups at positions 1, 6, 8S, 10S and 11 and a methyl group at position 8S. It is the aglycone of komodoquinone A which was isolated from the marine bacterium Streptomyces sp. KS3.
Structure
| Standard InChIKey | SFRTWZQYMRMOOJ-OVWNDWIMSA-N |
|---|---|
| SMILES | C[C@]1(C[C@@H](C2=C(C3=C(C(=C2C1)O)C(=O)C4=C(C3=O)C(=CC=C4)O)O)O)O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA019430 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, saccharide, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces erythrochromogenes NCBITaxon:285574 |
SOURCE_ASSERTION | mibig:BGC0001851 | DOI:10.1021/acschembio.9b00238 |
| Streptomyces sp. NRRL S-378 NCBITaxon:1463904 |
SOURCE_ASSERTION | mibig:BGC0001852 | DOI:10.1021/acschembio.9b00238 |
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1021/NP030212K |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1248/CPB.51.1402 |
| Streptomyces sp. NCBITaxon:1931 |
CHEBI | PMID:14646317 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001851 | Streptomyces erythrochromogenes NCBITaxon:285574 |
CLUSTER_DEMONSTRATED | genbank:NZ_JNZG01000006.1 |
| mibig:BGC0001852 | Streptomyces sp. NRRL S-378 NCBITaxon:1463904 |
CLUSTER_DEMONSTRATED | genbank:NZ_JOBX01000002.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0001851, BGC0001852. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001851 | MIBIG | 4 |
| BGC0001852 | MIBIG | 4 |
| CHEBI:167002 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/komodoquinone-b.yaml, which is generated from the committed inventories. Neither is edited by hand.