NaturalProductMech

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lasiodiplodin

naturalproductmech:mibig-a6debb22b8 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyOKWRDLQBKAOJNC-LBPRGKRZSA-N
SMILESC[C@H]1CCCCCCCC2=CC(=CC(=C2C(=O)O1)OC)O
Stereochemistryfully defined
Cross-referencespubchem:14562696

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Lasiodiplodia theobromae
NCBITaxon:45133		 SOURCE_ASSERTION mibig:BGC0001245 PMID:24597618

Occurrences 10

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Strychnos angustiflora
NCBITaxon:1040857		 LOTUS DOI:10.1016/J.BMCL.2016.08.019
Euphorbia plumerioides
NCBITaxon:212961		 LOTUS DOI:10.1016/0031-9422(91)84139-J
Annona dioica
NCBITaxon:2986273		 LOTUS DOI:10.1590/S0103-50532003000300009
Erycibe expansa
NCBITaxon:3804245		 LOTUS DOI:10.1248/CPB.54.1530
Ficus nervosa
NCBITaxon:463862		 LOTUS DOI:10.1002/CBDV.200900227
Garcinia mangostana
NCBITaxon:58228		 LOTUS DOI:10.1016/J.PHYTOL.2012.11.007
Euphorbia milii var. splendens
NCBITaxon:65560		 LOTUS DOI:10.1016/S0031-9422(00)82428-0
Lasiodiplodia theobromae
NCBITaxon:45133		 LOTUS DOI:10.1016/J.TET.2009.10.084
Lasiodiplodia theobromae
NCBITaxon:45133		 LOTUS DOI:10.1021/JF070082B
Lasiodiplodia theobromae
NCBITaxon:45133		 LOTUS DOI:10.1039/J39710001623

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0001245 Lasiodiplodia theobromae
NCBITaxon:45133 		CLUSTER_UNSTATED genbank:KJ434938.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (0 causal) 10 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT lasiodiplodin naturalproductmech:mibig-a6debb22b8 Polyketides TARGETS & BIOACTIVITY 0 molecular targets 0 bioactivities · 0 graphs

Explore across X-Mech

AntibioticMech (lasiodiplodin) ↗ MediaIngredientMech (naturalproductmech:mibig-a6debb22b8) ↗ TaxonMech: Lasiodiplodia theobromae (NCBITaxon:45133) ↗ PathwayMech (mibig:BGC0001245) ↗

Provenance

Source conceptSourceVersion
BGC0001245MIBIG3

This page is generated from data/natural_products/polyketides/lasiodiplodin.yaml, which is generated from the committed inventories. Neither is edited by hand.