lovastatin
naturalproductmech:mibig-1824ca86bb MINTED SEEDED
Structure
| Standard InChIKey | PCZOHLXUXFIOCF-YPQFMRJXSA-N |
|---|---|
| SMILES | [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@H](C)CC |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA09354, pubchem:129467 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Aspergillus terreus NCBITaxon:33178 |
SOURCE_ASSERTION | mibig:BGC0000088 | DOI:10.1016/j.fct.2019.110585 |
| Monascus pilosus NCBITaxon:89488 |
SOURCE_ASSERTION | mibig:BGC0000098 | PMID:18578535 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Aspergillus terreus NCBITaxon:33178 |
LOTUS | DOI:10.7164/ANTIBIOTICS.33.334 |
| Monascus pilosus NCBITaxon:89488 |
LOTUS | DOI:10.1021/JF800595K |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000088 | Aspergillus terreus NCBITaxon:33178 |
CLUSTER_UNSTATED | genbank:AH007774.2 |
| mibig:BGC0000098 | Monascus pilosus NCBITaxon:89488 |
CLUSTER_UNSTATED | genbank:DQ176595.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000088, BGC0000098. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000088 | MIBIG | 4 |
| BGC0000098 | MIBIG | 3 |
This page is generated from data/natural_products/polyketides/lovastatin.yaml, which is generated from the committed inventories. Neither is edited by hand.