macrolactin H
naturalproductmech:mibig-8f937b8f89 MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | XXDIJWSZFWZBRM-BXXMKNEZSA-N |
|---|---|
| SMILES | CC1CCC\C=C/C=C/C(O)CC(O)C\C=C/C=C/C(O)C\C=C\C=C/C(=O)O1 |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA018354 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Bacillus velezensis FZB42 NCBITaxon:326423 |
BGC_CHARACTERIZED | mibig:BGC0000181 | PMID:16707694 |
| Jeotgalibacillus marinus NCBITaxon:86667 |
SOURCE_ASSERTION | mibig:BGC0001383 | PMID:27130432 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Bacillus NCBITaxon:1386 |
LOTUS | DOI:10.7164/ANTIBIOTICS.54.333 |
| Bacillus velezensis NCBITaxon:492670 |
LOTUS | DOI:10.1128/JB.00052-06 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000181 | Bacillus velezensis FZB42 NCBITaxon:326423 |
CLUSTER_DEMONSTRATED | genbank:AJ634061.2 |
| mibig:BGC0001383 | Jeotgalibacillus marinus NCBITaxon:86667 |
CLUSTER_UNSTATED | genbank:KF815729.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000181, BGC0001383. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000181 | MIBIG | 5 |
| BGC0001383 | MIBIG | 3 |
This page is generated from data/natural_products/polyketides/macrolactin-h.yaml, which is generated from the committed inventories. Neither is edited by hand.