mensacaricin

naturalproductmech:mibig-08e62a89df MINTED SEEDED cytotoxic

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	WWNXYRCJJRRWAQ-ALCXHWRFSA-N
SMILES	C[C@H]1[C@H]([C@@]23C(=O)C4=C([C@@H]([C@@]2(O3)[C@H]([C@@]1(C(=O)[C@H]5[C@@H](O5)C)O)O)OC)C(=CC=C4)OC)O
Stereochemistry	fully defined
Cross-references	pubchem:403671

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces bottropensis NCBITaxon:42235	SOURCE_ASSERTION	mibig:BGC0001177	PMID:22162248

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces bottropensis NCBITaxon:42235	LOTUS	DOI:10.1002/CBIC.201100574

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001177	Streptomyces bottropensis NCBITaxon:42235	CLUSTER_DEMONSTRATED	genbank:KJ437437.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 17

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences. 8 identical imported entries were collapsed for display only.

Explore across X-Mech

AntibioticMech (mensacaricin) ↗ MediaIngredientMech (naturalproductmech:mibig-08e62a89df) ↗ TaxonMech: Streptomyces bottropensis (NCBITaxon:42235) ↗ PathwayMech (mibig:BGC0001177) ↗

Provenance

Source concept	Source	Version
BGC0001177	MIBIG	4

This page is generated from data/natural_products/polyketides/mensacaricin.yaml, which is generated from the committed inventories. Neither is edited by hand.

Assay	Result	Target enzyme	Source detail
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794775 assay NCI human tumor cell line growth inhibition assay. Data for the 786-0 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794775 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794775, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line	ACTIVE	Not recorded	pubchem.aid:137 assay NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line evidence reference pubchem.aid:137 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 137, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A498 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794774 assay NCI human tumor cell line growth inhibition assay. Data for the A498 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794774 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794774, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line	ACTIVE	Not recorded	pubchem.aid:129 assay NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line evidence reference pubchem.aid:129 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 129, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line	ACTIVE	Not recorded	pubchem.aid:19 assay NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line evidence reference pubchem.aid:19 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 19, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794740 assay NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794740 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794740, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the ACHN Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794771 assay NCI human tumor cell line growth inhibition assay. Data for the ACHN Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794771 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794771, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line	ACTIVE	Not recorded	pubchem.aid:139 assay NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line evidence reference pubchem.aid:139 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 139, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line	ACTIVE	Not recorded	pubchem.aid:89 assay NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line evidence reference pubchem.aid:89 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 89, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794793 assay NCI human tumor cell line growth inhibition assay. Data for the BT-549 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794793 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794793, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794772 assay NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794772 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794772, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line	ACTIVE	Not recorded	pubchem.aid:131 assay NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Renal cell line evidence reference pubchem.aid:131 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 131, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line	ACTIVE	Not recorded	pubchem.aid:119 assay NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line evidence reference pubchem.aid:119 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 119, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794778 assay NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794778 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794778, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line	ACTIVE	Not recorded	pubchem.aid:67 assay NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line evidence reference pubchem.aid:67 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 67, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794742 assay NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794742 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794742, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the DU-145 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794760 assay NCI human tumor cell line growth inhibition assay. Data for the DU-145 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794760 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794760, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC notes 153 further PubChem assay results are in data/raw/pubchem_bioassay.tsv but not written here.