monensin
naturalproductmech:mibig-7822673a33 MINTED SEEDED
Structure
| Standard InChIKey | GAOZTHIDHYLHMS-UHFFFAOYSA-N |
|---|---|
| SMILES | CCC1(CCC(O1)C1(C)CCC2(CC(O)C(C)C(O2)C(C)C(OC)C(C)C(O)=O)O1)C1OC(CC1C)C1OC(O)(CO)C(C)CC1C |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA010274, pubchem:4243 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces cinnamonensis NCBITaxon:1961 |
SOURCE_ASSERTION | mibig:BGC0000100 | PMID:12940979 |
| Streptomyces cinnamonensis NCBITaxon:1961 |
SOURCE_ASSERTION | mibig:BGC0001670 | PMID:27718094 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces cinnamonensis NCBITaxon:1961 |
LOTUS | DOI:10.1007/S10295-016-1845-4 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000100 | Streptomyces cinnamonensis NCBITaxon:1961 |
CLUSTER_UNSTATED | genbank:AF440781.1 |
| mibig:BGC0001670 | Streptomyces cinnamonensis NCBITaxon:1961 |
CLUSTER_UNSTATED | genbank:KX263301.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000100, BGC0001670. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000100 | MIBIG | 5 |
| BGC0001670 | MIBIG | 5 |
This page is generated from data/natural_products/polyketides/monensin.yaml, which is generated from the committed inventories. Neither is edited by hand.