monocillin VI
naturalproductmech:mibig-bfb8625ab0 MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | PUBJBUSNXLSOQM-YWDVGMFKSA-N |
|---|---|
| SMILES | C[C@H]1OC(=O)C2=C(C=C(O)C=C2O)CC(=O)CCCC/C=C/[C@@H]1O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:406870989, npatlas:NPA026290 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Pochonia chlamydosporia 170 NCBITaxon:1380566 |
SOURCE_ASSERTION | mibig:BGC0002187 | DOI:10.1021/acs.jafc.9b01977 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Metacordyceps chlamydosporia NCBITaxon:280754 |
LOTUS | DOI:10.1021/ACS.JAFC.9B01977 |
| Paecilomyces NCBITaxon:33202 |
LOTUS | DOI:10.1021/ACS.JNATPROD.7B00066 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002187 | Pochonia chlamydosporia 170 NCBITaxon:1380566 |
CLUSTER_UNSTATED | genbank:CM008060.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002187 | MIBIG | 3 |
This page is generated from data/natural_products/polyketides/monocillin-vi.yaml, which is generated from the committed inventories. Neither is edited by hand.