murayaquinone

naturalproductmech:mibig-88261c35cc MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	YJQYHFMKGAVKDP-UHFFFAOYSA-N
SMILES	CCCC(=O)C1=CC2=C(C(O)=C1C)C(=O)C(=O)C1=C2C=CC=C1O
Stereochemistry	fully defined
Cross-references	npatlas:NPA016238

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces griseoruber NCBITaxon:1943	SOURCE_ASSERTION	mibig:BGC0001675	PMID:28712746

Occurrences 5

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces lividans NCBITaxon:1916	LOTUS	DOI:10.3389/FMICB.2018.03042
Streptomyces murayamaensis NCBITaxon:224537	LOTUS	DOI:10.1016/S0040-4020(97)00226-3
Streptomyces murayamaensis NCBITaxon:224537	LOTUS	DOI:10.1016/S0040-4039(00)83962-3
Streptomyces murayamaensis NCBITaxon:224537	LOTUS	DOI:10.7164/ANTIBIOTICS.42.179
Aspergillus ochraceus NCBITaxon:40380	LOTUS	DOI:10.1021/NP000381U

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001675	Streptomyces griseoruber NCBITaxon:1943	CLUSTER_UNSTATED	genbank:KX817190.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Biosynthesis curated

Written by a curator with claim-level evidence on each step; not derived from a source. This is what the rest of the record exists to support.

Step	Enzyme	Reaction	Substrate → product	Evidence
1	MrqO5 cofactor-independent monooxygenase UniProtKB:A0A1S6QMP3		ungrounded → ungrounded	DOI:10.1021/acschembio.5c00695

Step 1: MrqO5 decarboxylates an aromatic type II polyketide biosynthesis intermediate in the murayaquinone pathway. This single-step partial pathway leaves assembly of the upstream carboxylated intermediate and its later conversion to murayaquinone uncurated.

Mechanism & Biosynthesis Overview

Causal graph — biosynthesis 3 nodes, 2 edges

Partial Streptomyces griseoruber murayaquinone biosynthesis graph for MrqO5-catalyzed decarboxylation of an aromatic type II polyketide intermediate.

Subject	Predicate	Object	Notes	Evidence
carboxylated aromatic type II polyketide intermediate	is decarboxylated by	MrqO5 cofactor-independent monooxygenase	MITE records MrqO5 as the cofactor-independent monooxygenase for decarboxylation of an aromatic type II polyketide murayaquinone-pathway intermediate.	DOI:10.1021/acschembio.5c00695 https://mite.lisc.univie.ac.at/repository/MITE0000465 https://mibig.secondarymetabolites.org/repository/BGC0001675.5/BGC0001675.gbk https://www.uniprot.org/uniprotkb/A0A1S6QMP3 https://www.ncbi.nlm.nih.gov/protein/AQW35073.1 reference DOI:10.1021/acschembio.5c00695 evidence type PRIMARY_EXPERIMENT snippet Decarboxylase Activity of an Antibiotic Biosynthesis Monooxygenase Family Protein in the Biosynthesis of the Type II Polyketide Murayaquinone notes Zhou et al. characterized decarboxylase activity from a monooxygenase-family protein in type II polyketide murayaquinone biosynthesis; MITE curates MrqO5 from this DOI as an in vitro decarboxylation reaction. reference https://mite.lisc.univie.ac.at/repository/MITE0000465 evidence type DATABASE_ASSERTION snippet Decarboxylation of aromatic type II polyketide biosynthesis intermediate retrieved on 2026-10-01 notes MITE0000465 is an active MrqO5 cofactor-independent monooxygenase entry for decarboxylation of an aromatic type II polyketide murayaquinone biosynthesis intermediate; it links UniProtKB:A0A1S6QMP3, GenPept AQW35073.1, MIBiG BGC0001675 and the Zhou et al. DOI. reference https://mibig.secondarymetabolites.org/repository/BGC0001675.5/BGC0001675.gbk evidence type DATABASE_ASSERTION snippet protein_id="AQW35073.1" retrieved on 2026-10-01 notes MIBiG BGC0001675.5 places AQW35073.1 inside the active Streptomyces griseoruber Sgr29 murayaquinone cluster as the mrqO5 oxygenase CDS. reference https://www.uniprot.org/uniprotkb/A0A1S6QMP3 evidence type DATABASE_ASSERTION snippet GN Name=mrqO5 retrieved on 2026-10-01 notes Current unreviewed UniProtKB:A0A1S6QMP3 resolves as a 103 aa Streptomyces griseoruber MrqO5 oxygenase and cross-references EMBL KX817190 protein AQW35073.1. reference https://www.ncbi.nlm.nih.gov/protein/AQW35073.1 evidence type DATABASE_ASSERTION snippet oxygenase [Streptomyces griseoruber] retrieved on 2026-10-01 notes GenPept AQW35073.1 is the 103 aa Streptomyces griseoruber Sgr29 oxygenase encoded by complement(KX817190.1:58328..58639) with gene qualifier mrqO5.
MrqO5 cofactor-independent monooxygenase	forms	decarboxylated aromatic type II polyketide intermediate	This graph stops at the decarboxylated intermediate because MITE0000465 marks the substrate and product as intermediates rather than final murayaquinone.	DOI:10.1021/acschembio.5c00695 https://mite.lisc.univie.ac.at/repository/MITE0000465 https://mibig.secondarymetabolites.org/repository/BGC0001675.5/BGC0001675.gbk https://www.uniprot.org/uniprotkb/A0A1S6QMP3 https://www.ncbi.nlm.nih.gov/protein/AQW35073.1 reference DOI:10.1021/acschembio.5c00695 evidence type PRIMARY_EXPERIMENT snippet Decarboxylase Activity of an Antibiotic Biosynthesis Monooxygenase Family Protein in the Biosynthesis of the Type II Polyketide Murayaquinone notes Zhou et al. characterized decarboxylase activity from a monooxygenase-family protein in type II polyketide murayaquinone biosynthesis; MITE curates MrqO5 from this DOI as an in vitro decarboxylation reaction. reference https://mite.lisc.univie.ac.at/repository/MITE0000465 evidence type DATABASE_ASSERTION snippet Decarboxylation of aromatic type II polyketide biosynthesis intermediate retrieved on 2026-10-01 notes MITE0000465 is an active MrqO5 cofactor-independent monooxygenase entry for decarboxylation of an aromatic type II polyketide murayaquinone biosynthesis intermediate; it links UniProtKB:A0A1S6QMP3, GenPept AQW35073.1, MIBiG BGC0001675 and the Zhou et al. DOI. reference https://mibig.secondarymetabolites.org/repository/BGC0001675.5/BGC0001675.gbk evidence type DATABASE_ASSERTION snippet protein_id="AQW35073.1" retrieved on 2026-10-01 notes MIBiG BGC0001675.5 places AQW35073.1 inside the active Streptomyces griseoruber Sgr29 murayaquinone cluster as the mrqO5 oxygenase CDS. reference https://www.uniprot.org/uniprotkb/A0A1S6QMP3 evidence type DATABASE_ASSERTION snippet GN Name=mrqO5 retrieved on 2026-10-01 notes Current unreviewed UniProtKB:A0A1S6QMP3 resolves as a 103 aa Streptomyces griseoruber MrqO5 oxygenase and cross-references EMBL KX817190 protein AQW35073.1. reference https://www.ncbi.nlm.nih.gov/protein/AQW35073.1 evidence type DATABASE_ASSERTION snippet oxygenase [Streptomyces griseoruber] retrieved on 2026-10-01 notes GenPept AQW35073.1 is the 103 aa Streptomyces griseoruber Sgr29 oxygenase encoded by complement(KX817190.1:58328..58639) with gene qualifier mrqO5.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Explore across X-Mech

AntibioticMech (murayaquinone) ↗ MediaIngredientMech (naturalproductmech:mibig-88261c35cc) ↗ TaxonMech: Streptomyces griseoruber (NCBITaxon:1943) ↗ PathwayMech (mibig:BGC0001675) ↗

Provenance

Source concept	Source	Version
BGC0001675	MIBIG	5

This page is generated from data/natural_products/polyketides/murayaquinone.yaml, which is generated from the committed inventories. Neither is edited by hand.