narbomycin
CHEBI:29649 EXACT SEEDED antibacterial
A macrolide antibiotic that is narbonolide having a 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl residue attached at position 6. It is biosynthesised by Streptomyces venezuelae.
Structure
| Standard InChIKey | OXFYAOOMMKGGAI-JLTOUBQASA-N |
|---|---|
| SMILES | CC[C@@H]1[C@@H](/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]2[C@@H]([C@H](C[C@H](O2)C)N(C)C)O)C)C)C |
| Stereochemistry | fully defined |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is saccharide, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces venezuelae NCBITaxon:54571 |
SOURCE_ASSERTION | mibig:BGC0000898 | PMID:9770448 |
Occurrences 9
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1007/S10295-018-2024-6 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1016/J.CHEMBIOL.2009.08.010 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1016/J.JBIOTEC.2015.12.028 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1016/S0378-1119(00)00560-6 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1016/S1074-5521(98)90293-9 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1038/NBT0702-713 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1073/PNAS.95.21.12111 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1074/JBC.M605478200 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1074/JBC.M807592200 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000898 | Streptomyces venezuelae NCBITaxon:54571 |
CLUSTER_UNSTATED | genbank:AF079762.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:29649 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000898 | MIBIG | 5 |
| CHEBI:29649 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/narbomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.