nogalamycin
naturalproductmech:mibig-7aff864d10 MINTED SEEDED antiparasitic
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | HXCSJGHKDZKLKV-KCTIBYJUSA-N |
|---|---|
| SMILES | CO[C@H]1C[C@](C)(O)[C@H](C(=O)OC)C2=C1C(O)=C1C(=O)C3=C(O)C=C4C(O[C@@H]5O[C@@]4(C)[C@H](O)[C@H]([C@@H]5O)N(C)C)=C3C(=O)C1=C2 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA07304, pubchem:5289019 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces nogalater NCBITaxon:38314 |
SOURCE_ASSERTION | mibig:BGC0000249 | PMID:8668120 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces nogalater NCBITaxon:38314 |
LOTUS | DOI:10.1007/BF02172908 |
| Streptomyces nogalater NCBITaxon:38314 |
LOTUS | DOI:10.1016/S0040-4039(00)75607-3 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000249 | Streptomyces nogalater NCBITaxon:38314 |
CLUSTER_UNSTATED | genbank:AF323753.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Bioactivities 2
Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.
| Assay | Result | Target enzyme | Source detail |
|---|---|---|---|
| DNA Helicase Assay from Article 10.1186/1471-2091-15-9: "Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth." | IC50 3.5 uM; ACTIVE | Not recorded | PMID:24707807
|
| DNA-Dependent ATPase Assay from Article 10.1186/1471-2091-15-9: "Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth." | IC50 3.3 uM; ACTIVE | Not recorded | PMID:24707807
|
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000249 | MIBIG | 5 |
This page is generated from data/natural_products/polyketides/nogalamycin.yaml, which is generated from the committed inventories. Neither is edited by hand.