oviedomycin
CHEBI:156291 EXACT SEEDED antimicrobial unspecified
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A member of the class of tetraphenes that is 1,4,7,12-tetrahydrotetraphene substituted by oxo groups at positions 1, 4, 7, and 12, by hydroxy groups at positions 2, 6 and 8, and by a methyl group at position 3. It is a natural product found in Streptomyces antibioticus ATCC 11891 which exhibits cytotoxicity against A549 human lung cancer cells, HepG2 liver cancer cells, and MCF-7 breast cancer cells.
Structure
| Standard InChIKey | LRVJUCBWMNTDLP-UHFFFAOYSA-N |
|---|---|
| SMILES | CC1=C(O)C(=O)C2=C(C=C(O)C3=C2C(=O)C2=CC=CC(O)=C2C3=O)C1=O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA018728, pubchem:5323531 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces antibioticus NCBITaxon:1890 |
BGC_CHARACTERIZED | mibig:BGC0000253 | PMID:15368568 |
| Streptomyces antibioticus NCBITaxon:1890 |
SOURCE_ASSERTION | mibig:BGC0001723 | PMID:28562006 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces ansochromogenes NCBITaxon:115647 |
CHEBI | PMID:28972184 |
| Streptomyces antibioticus NCBITaxon:1890 |
LOTUS | DOI:10.1002/CBIC.200400073 |
| Streptomyces antibioticus NCBITaxon:1890 |
LOTUS | DOI:10.1021/NP010555N |
| Streptomyces antibioticus NCBITaxon:1890 |
CHEBI | PMID:15368568 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000253 | Streptomyces antibioticus NCBITaxon:1890 |
CLUSTER_DEMONSTRATED | genbank:AJ632203.2 |
| mibig:BGC0001723 | Streptomyces antibioticus NCBITaxon:1890 |
CLUSTER_UNSTATED | genbank:KY129858.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:156291 (same structure, same inchikey)
Explore across X-Mech
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000253, BGC0001723. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000253 | MIBIG | 4 |
| BGC0001723 | MIBIG | 5 |
| CHEBI:156291 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/oviedomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.