peloruside A
CHEBI:77692 EXACT SEEDED
A macrolide that is a novel secondary metabolite isolated from a New Zealand marine sponge, Mycale hentscheli.
Structure
| Standard InChIKey | NETARJWZTMGMRM-JRTPPQMASA-N |
|---|---|
| SMILES | CC[C@H](CO)/C=C(/C)\[C@H]1C[C@@H](C[C@H](C([C@]2([C@H]([C@H](C[C@H](O2)C[C@@H]([C@H](C(=O)O1)O)OC)OC)O)O)(C)C)O)OC |
| Stereochemistry | fully defined |
| Cross-references | pubchem:6918506 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 0
None. The compound has a characterized gene cluster whose host NCBI does not name, which for an uncultured symbiont is the honest state — see the discussion below.
Occurrences 3
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Mycale hentscheli NCBITaxon:659499 |
LOTUS | DOI:10.1007/S10637-010-9398-2 |
| Mycale hentscheli NCBITaxon:659499 |
LOTUS | DOI:10.1023/B:APPT.0000045789.54694.CF |
| Mycale NCBITaxon:86015 |
LOTUS | DOI:10.1021/JO991296Y |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002056 | not named | CLUSTER_UNSTATED | genbank:JAAHTH010000242.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
unnamed-producer — No producer claim is written from BGC0002056, which gives NCBITaxon:1163772 (under metagenomes — a community, not an organism), because the taxon names no single organism. The cluster is kept: a characterized locus is an origin assertion whether or not its host has a name, and for a compound from an uncultured symbiont that is the honest state. Name the producer if the primary literature does.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002056 | MIBIG | 3 |
| CHEBI:77692 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/peloruside-a.yaml, which is generated from the committed inventories. Neither is edited by hand.