pladienolide B
naturalproductmech:mibig-f21202a3e0 MINTED SEEDED
Structure
| Standard InChIKey | SDOUORKJIJYJNW-VHSLCUDQSA-N |
|---|---|
| SMILES | CCC(C(C)C1C(O1)CC(C)/C=C/C=C(\C)/C2C(/C=C/C(C(CCC(CC(=O)O2)O)(C)O)OC(=O)C)C)O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA008881, npatlas:NPA08881 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces platensis NCBITaxon:58346 |
BGC_CHARACTERIZED | mibig:BGC0002102 | DOI:10.7164/antibiotics.57.188 |
| Streptomyces platensis NCBITaxon:58346 |
SOURCE_ASSERTION | mibig:BGC0000126 | PMID:18997414 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1271/BBB.80425 |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.7164/ANTIBIOTICS.57.173 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002102 | Streptomyces platensis NCBITaxon:58346 |
CLUSTER_DEMONSTRATED | genbank:MN974405.1 |
| mibig:BGC0000126 | Streptomyces platensis NCBITaxon:58346 |
CLUSTER_UNSTATED | genbank:AB435553.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000126, BGC0002102. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002102 | MIBIG | 2 |
| BGC0000126 | MIBIG | 5 |
This page is generated from data/natural_products/polyketides/pladienolide-b.yaml, which is generated from the committed inventories. Neither is edited by hand.