pradimicin A
CHEBI:8349 EXACT SEEDED antifungal
A member of the class of pradimicins that is isolated from the cultured broth of Actinomadura hibisca No. P157-2 (ATCC 53557).
Structure
| Standard InChIKey | WPICPWIIIBCXCV-NJGWPHBESA-N |
|---|---|
| SMILES | [H][C@](C)(NC(=O)C1=C(O)C2=C(C=C1C)[C@H](O[C@@H]1O[C@H](C)[C@H](NC)[C@H](O[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)[C@H]1O)[C@@H](O)C1=CC3=C(C(O)=C21)C(=O)C1=C(C(O)=CC(OC)=C1)C3=O)C(O)=O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA08193 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Actinomadura hibisca NCBITaxon:68565 |
SOURCE_ASSERTION | mibig:BGC0000256 | PMID:18051306 |
Occurrences 6
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Actinomadura hibisca NCBITaxon:68565 |
CHEBI | 10.1021/jo00272a013 |
| Actinomadura hibisca NCBITaxon:68565 |
LOTUS | DOI:10.1021/JO00272A013 |
| Actinomadura hibisca NCBITaxon:68565 |
LOTUS | DOI:10.1021/JO00272A014 |
| Actinomadura hibisca NCBITaxon:68565 |
LOTUS | DOI:10.7164/ANTIBIOTICS.41.1701 |
| Actinomadura hibisca NCBITaxon:68565 |
LOTUS | DOI:10.7164/ANTIBIOTICS.43.1367 |
| Actinomadura hibisca NCBITaxon:68565 |
LOTUS | DOI:10.7164/ANTIBIOTICS.43.755 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000256 | Actinomadura hibisca NCBITaxon:68565 |
CLUSTER_UNSTATED | genbank:EF151801.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:8349 (same structure, same inchikey)
Open questions 1
name-disagreement — ChEBI calls this structure 'pradimicin A' and MIBiG calls it 'pradimicin-A'. They share a Standard InChIKey, so if the names denote different compounds then one upstream record has the wrong structure. Check which.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000256 | MIBIG | 3 |
| CHEBI:8349 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/pradimicin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.