rabelomycin
naturalproductmech:mibig-ec6ca029f7 MINTED SEEDED
Structure
| Standard InChIKey | JJOLHRYZQSDLSA-IBGZPJMESA-N |
|---|---|
| SMILES | C[C@@]1(O)CC(=O)C2=C3C(=O)C4=C(C(O)=CC=C4)C(=O)C3=C(O)C=C2C1 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA019619, pubchem:443810 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, saccharide, from MIBiG.
Producer organisms 3
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. PGA64 NCBITaxon:161235 |
BGC_CORRELATED | mibig:BGC0000262 | PMID:12654660 |
| uncultured bacterium BAC AB649/1850 NCBITaxon:1037453 |
SOURCE_ASSERTION | mibig:BGC0000223 | PMID:20690632 |
| Micromonospora rosaria NCBITaxon:47874 |
SOURCE_ASSERTION | mibig:BGC0001904 | DOI:10.1021/acs.orglett.5b02683 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces olivaceus NCBITaxon:47716 |
LOTUS | DOI:10.7164/ANTIBIOTICS.23.437 |
Biosynthetic gene clusters 3
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000262 | Streptomyces sp. PGA64 NCBITaxon:161235 |
CLUSTER_DEMONSTRATED | genbank:AY034378.2 |
| mibig:BGC0000223 | uncultured bacterium BAC AB649/1850 NCBITaxon:1037453 |
CLUSTER_DEMONSTRATED | genbank:HM193369.1 |
| mibig:BGC0001904 | Micromonospora rosaria NCBITaxon:47874 |
CLUSTER_UNSTATED | genbank:KT726162.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000223, BGC0000262, BGC0001904. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000262 | MIBIG | 5 |
| BGC0000223 | MIBIG | 5 |
| BGC0001904 | MIBIG | 2 |
This page is generated from data/natural_products/polyketides/rabelomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.