rhodomycin

naturalproductmech:mibig-b66ae2776e MINTED SEEDED cytotoxic

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	NWPIUETWDSWOKV-QROLFQDOSA-N
SMILES	CC[C@]1(C[C@@H](C2=C(C3=C(C(=C2[C@H]1OC4CC(C(C(O4)C)O)N(C)C)O)C(=O)C5=C(C3=O)C(=CC=C5)O)O)OC6CC(C(C(O6)C)O)N(C)C)O
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	pubchem:5351236

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces purpurascens NCBITaxon:1924	SOURCE_ASSERTION	mibig:BGC0000265	PMID:8081500

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces violaceus NCBITaxon:1936	LOTUS	DOI:10.1099/00221287-140-6-1351
Streptomyces purpurascens NCBITaxon:1924	LOTUS	DOI:10.1099/00221287-140-6-1351

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000265	Streptomyces purpurascens NCBITaxon:1924	CLUSTER_UNSTATED	genbank:U10405.2

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 25

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Explore across X-Mech

AntibioticMech (rhodomycin) ↗ MediaIngredientMech (naturalproductmech:mibig-b66ae2776e) ↗ TaxonMech: Streptomyces purpurascens (NCBITaxon:1924) ↗ PathwayMech (mibig:BGC0000265) ↗

Provenance

Source concept	Source	Version
BGC0000265	MIBIG	5

This page is generated from data/natural_products/polyketides/rhodomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.

Assay	Result	Target enzyme	Source detail
NCI Yeast Anticancer Drug Screen. Data for the CLN2oe strain	ACTIVE	Not recorded	pubchem.aid:163 assay NCI Yeast Anticancer Drug Screen. Data for the CLN2oe strain evidence reference pubchem.aid:163 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 163, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the bub3 strain	ACTIVE	Not recorded	pubchem.aid:167 assay NCI Yeast Anticancer Drug Screen. Data for the bub3 strain evidence reference pubchem.aid:167 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 167, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain	ACTIVE	Not recorded	pubchem.aid:165 assay NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain evidence reference pubchem.aid:165 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 165, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain	ACTIVE	Not recorded	pubchem.aid:157 assay NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain evidence reference pubchem.aid:157 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 157, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the mgt1 strain	ACTIVE	Not recorded	pubchem.aid:153 assay NCI Yeast Anticancer Drug Screen. Data for the mgt1 strain evidence reference pubchem.aid:153 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 153, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain	ACTIVE	Not recorded	pubchem.aid:175 assay NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain evidence reference pubchem.aid:175 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 175, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the mlh1 strain	ACTIVE	Not recorded	pubchem.aid:171 assay NCI Yeast Anticancer Drug Screen. Data for the mlh1 strain evidence reference pubchem.aid:171 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 171, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the rad14 strain	ACTIVE	Not recorded	pubchem.aid:159 assay NCI Yeast Anticancer Drug Screen. Data for the rad14 strain evidence reference pubchem.aid:159 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 159, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the rad18 strain	ACTIVE	Not recorded	pubchem.aid:177 assay NCI Yeast Anticancer Drug Screen. Data for the rad18 strain evidence reference pubchem.aid:177 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 177, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the rad50 strain	ACTIVE	Not recorded	pubchem.aid:155 assay NCI Yeast Anticancer Drug Screen. Data for the rad50 strain evidence reference pubchem.aid:155 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 155, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the rad52 strain	ACTIVE	Not recorded	pubchem.aid:147 assay NCI Yeast Anticancer Drug Screen. Data for the rad52 strain evidence reference pubchem.aid:147 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 147, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain	ACTIVE	Not recorded	pubchem.aid:161 assay NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain evidence reference pubchem.aid:161 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 161, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the sgs1 strain	ACTIVE	Not recorded	pubchem.aid:173 assay NCI Yeast Anticancer Drug Screen. Data for the sgs1 strain evidence reference pubchem.aid:173 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 173, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI Yeast Anticancer Drug Screen. Data for the wt2 strain	ACTIVE	Not recorded	pubchem.aid:169 assay NCI Yeast Anticancer Drug Screen. Data for the wt2 strain evidence reference pubchem.aid:169 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 169, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794775 assay NCI human tumor cell line growth inhibition assay. Data for the 786-0 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794775 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794775, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line	ACTIVE	Not recorded	pubchem.aid:137 assay NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line evidence reference pubchem.aid:137 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 137, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A498 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794774 assay NCI human tumor cell line growth inhibition assay. Data for the A498 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794774 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794774, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line	ACTIVE	Not recorded	pubchem.aid:129 assay NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line evidence reference pubchem.aid:129 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 129, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line	ACTIVE	Not recorded	pubchem.aid:19 assay NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line evidence reference pubchem.aid:19 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 19, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794740 assay NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794740 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794740, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the ACHN Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794771 assay NCI human tumor cell line growth inhibition assay. Data for the ACHN Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794771 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794771, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line	ACTIVE	Not recorded	pubchem.aid:139 assay NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line evidence reference pubchem.aid:139 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 139, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line	ACTIVE	Not recorded	pubchem.aid:89 assay NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line evidence reference pubchem.aid:89 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 89, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the BT-549 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794793 assay NCI human tumor cell line growth inhibition assay. Data for the BT-549 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794793 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794793, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Non-Small Cell Lung cell line, single concentration	ACTIVE	Not recorded	pubchem.aid:1794772 assay NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Non-Small Cell Lung cell line, single concentration evidence reference pubchem.aid:1794772 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1794772, deposited by DTP/NCI; assay type Screening. call ACTIVE activity class CYTOTOXIC notes 103 further PubChem assay results are in data/raw/pubchem_bioassay.tsv but not written here.