rhodomycin
naturalproductmech:mibig-b66ae2776e MINTED SEEDED cytotoxic
Structure
| Standard InChIKey | NWPIUETWDSWOKV-QROLFQDOSA-N |
|---|---|
| SMILES | CC[C@]1(C[C@@H](C2=C(C3=C(C(=C2[C@H]1OC4CC(C(C(O4)C)O)N(C)C)O)C(=O)C5=C(C3=O)C(=CC=C5)O)O)OC6CC(C(C(O6)C)O)N(C)C)O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | pubchem:5351236 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces purpurascens NCBITaxon:1924 |
SOURCE_ASSERTION | mibig:BGC0000265 | PMID:8081500 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces violaceus NCBITaxon:1936 |
LOTUS | DOI:10.1099/00221287-140-6-1351 |
| Streptomyces purpurascens NCBITaxon:1924 |
LOTUS | DOI:10.1099/00221287-140-6-1351 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000265 | Streptomyces purpurascens NCBITaxon:1924 |
CLUSTER_UNSTATED | genbank:U10405.2 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 25
| Assay | Result | Reference |
|---|---|---|
| NCI Yeast Anticancer Drug Screen. Data for the CLN2oe strain | ACTIVE | pubchem.aid:163 |
| NCI Yeast Anticancer Drug Screen. Data for the bub3 strain | ACTIVE | pubchem.aid:167 |
| NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain | ACTIVE | pubchem.aid:165 |
| NCI Yeast Anticancer Drug Screen. Data for the mec2-1 strain | ACTIVE | pubchem.aid:157 |
| NCI Yeast Anticancer Drug Screen. Data for the mgt1 strain | ACTIVE | pubchem.aid:153 |
| NCI Yeast Anticancer Drug Screen. Data for the mlh1 rad18 strain | ACTIVE | pubchem.aid:175 |
| NCI Yeast Anticancer Drug Screen. Data for the mlh1 strain | ACTIVE | pubchem.aid:171 |
| NCI Yeast Anticancer Drug Screen. Data for the rad14 strain | ACTIVE | pubchem.aid:159 |
| NCI Yeast Anticancer Drug Screen. Data for the rad18 strain | ACTIVE | pubchem.aid:177 |
| NCI Yeast Anticancer Drug Screen. Data for the rad50 strain | ACTIVE | pubchem.aid:155 |
| NCI Yeast Anticancer Drug Screen. Data for the rad52 strain | ACTIVE | pubchem.aid:147 |
| NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain | ACTIVE | pubchem.aid:161 |
| NCI Yeast Anticancer Drug Screen. Data for the sgs1 strain | ACTIVE | pubchem.aid:173 |
| NCI Yeast Anticancer Drug Screen. Data for the wt2 strain | ACTIVE | pubchem.aid:169 |
| NCI human tumor cell line growth inhibition assay. Data for the 786-0 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794775 |
| NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line | ACTIVE | pubchem.aid:137 |
| NCI human tumor cell line growth inhibition assay. Data for the A498 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794774 |
| NCI human tumor cell line growth inhibition assay. Data for the A498 Renal cell line | ACTIVE | pubchem.aid:129 |
| NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line | ACTIVE | pubchem.aid:19 |
| NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794740 |
| NCI human tumor cell line growth inhibition assay. Data for the ACHN Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794771 |
| NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line | ACTIVE | pubchem.aid:139 |
| NCI human tumor cell line growth inhibition assay. Data for the BT-549 Breast cell line | ACTIVE | pubchem.aid:89 |
| NCI human tumor cell line growth inhibition assay. Data for the BT-549 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794793 |
| NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Non-Small Cell Lung cell line, single concentration | ACTIVE | pubchem.aid:1794772 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000265 | MIBIG | 5 |
This page is generated from data/natural_products/polyketides/rhodomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.