rosaramicin
CHEBI:87084 EXACT SEEDED antibacterial
A macrolide antibiotic with activity against Neisseria gonorrhoeae, Chlamydia trachomatis, Ureaplasma urealyticum and Mycoplasma hominis.
Structure
| Standard InChIKey | IUPCWCLVECYZRV-JZMZINANSA-N |
|---|---|
| SMILES | CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/[C@]2(C)O[C@H]2[C@@H]1C |
| Stereochemistry | fully defined |
| Cross-references | pubchem:6537204, npatlas:NPA004259 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Micromonospora carbonacea NCBITaxon:47853 |
SOURCE_ASSERTION | mibig:BGC0002086 | PMID:25930739 |
Occurrences 5
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Micromonospora NCBITaxon:1873 |
LOTUS | DOI:10.7164/ANTIBIOTICS.43.938 |
| Micromonospora rosaria NCBITaxon:47874 |
CHEBI | 10.1099/00207713-36-3-478 |
| Micromonospora rosaria NCBITaxon:47874 |
LOTUS | DOI:10.1039/C3972001270A |
| Micromonospora rosaria NCBITaxon:47874 |
LOTUS | DOI:10.1099/00207713-36-3-478 |
| Micromonospora rosaria NCBITaxon:47874 |
LOTUS | DOI:10.7164/ANTIBIOTICS.43.1497 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002086 | Micromonospora carbonacea NCBITaxon:47853 |
CLUSTER_UNSTATED | genbank:CP058322.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:87084 (same structure, same inchikey)
Open questions 1
name-disagreement — ChEBI calls this structure 'rosaramicin' and MIBiG calls it 'rosamicin'. They share a Standard InChIKey, so if the names denote different compounds then one upstream record has the wrong structure. Check which.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002086 | MIBIG | 3 |
| CHEBI:87084 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/rosaramicin.yaml, which is generated from the committed inventories. Neither is edited by hand.