salinomycin

naturalproductmech:mibig-90cc844890 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	KQXDHUJYNAXLNZ-SDCJTGBBSA-N
SMILES	CC[C@H]([C@@H]1[C@H](C[C@H]([C@@]2(O1)C=C[C@H]([C@]3(O2)CC[C@@](O3)(C)[C@H]4CC[C@@]([C@@H](O4)C)(CC)O)O)C)C)C(=O)[C@@H](C)[C@H]([C@H](C)[C@H]5[C@H](CCC(O5)[C@@H](CC)C(=O)O)C)O
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	pubchem:72370

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces albus NCBITaxon:1888	BGC_CHARACTERIZED	mibig:BGC0000144	PMID:22156425

Occurrences 12

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces albus NCBITaxon:1888	LOTUS	DOI:10.1007/BF02879490
Streptomyces albus NCBITaxon:1888	LOTUS	DOI:10.1007/S00253-008-1591-2
Streptomyces albus NCBITaxon:1888	LOTUS	DOI:10.1007/S11427-017-9122-8
Streptomyces albus NCBITaxon:1888	LOTUS	DOI:10.1007/S11427-018-9474-7
Streptomyces albus NCBITaxon:1888	LOTUS	DOI:10.1016/J.JPBA.2005.05.006
Streptomyces albus NCBITaxon:1888	LOTUS	DOI:10.1016/J.YMBEN.2016.02.012
Streptomyces albus NCBITaxon:1888	LOTUS	DOI:10.1017/S0031182018001919
Streptomyces albus NCBITaxon:1888	LOTUS	DOI:10.1038/SREP15081
Streptomyces albus NCBITaxon:1888	LOTUS	DOI:10.1111/J.1574-6968.2000.TB08868.X
Streptomyces albus NCBITaxon:1888	LOTUS	DOI:10.1128/AEM.06701-11
Streptomyces albus NCBITaxon:1888	LOTUS	DOI:10.3389/FBIOE.2019.00212
Streptomyces albus NCBITaxon:1888	LOTUS	DOI:10.3390/MD17060347

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000144	Streptomyces albus NCBITaxon:1888	CLUSTER_DEMONSTRATED	genbank:JN033543.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Causal graph — biosynthesis 4 nodes, 3 edges

MITE-reported SlnM double-bond and bis(spiroacetal) formation in a salinomycin biosynthesis context. Native Streptomyces albus XM211 reference identity is independently sequence-verified, not its catalytic activity. The database example matches this owner's incomplete stereochemical resolution, not a fully resolved stereoisomer. No methylation, native cofactor state, primary assay or pathway finality is inferred; not full-record sign-off.

Subject	Predicate	Object	Notes	Evidence
SlnM native XM211 reference	is_database_reported_catalyst_of	MITE-reported double-bond and bis(spiroacetal) formation	MITE supplies the functional assignment; sequence evidence establishes identity only. Exact NCBIProtein grounding is used without substituting an arbitrary current UniProt homolog. No assay, activity magnitude, knockout phenotype, methylation, site, SAM state or physical complex is inferred.	https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000441.json https://www.ncbi.nlm.nih.gov/protein/AEZ53956.1 https://www.ncbi.nlm.nih.gov/nuccore/JN033543.1 https://www.uniprot.org/uniparc/UPI000247F579 reference https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000441.json evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes MITE0000441 version 1, active, identifies SlnM/AEZ53956.1 and BGC0000144. The reaction description assigns 18,19-double-bond and bis(spiroacetal) formation, not ordinary O-methylation despite the enzyme family label. Heterologous, in-vitro, knockout and mutagenesis codes remain database assertions; both cited primary papers were inaccessible. No primary assay or native cofactor state is adopted. snippet double bond and bis(spiroacetal) reference https://www.ncbi.nlm.nih.gov/protein/AEZ53956.1 evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes Complete independent GenPept reference and coded_by inspected: slnM, 271 residues, S.albus XM211/taxon1888. Its O-methyltransferase label does not independently establish the compound-specific reaction. reference https://www.ncbi.nlm.nih.gov/nuccore/JN033543.1 evidence type CURATOR_INFERENCE retrieved on 2026-10-07 notes Complete 816-nt plus-strand CDS93645..94460, codon1/table11, translates exactly to the CDS annotation, independent AEZ53956.1 and UniParc, all271aa. Independent coded_by DNA/coordinates and genomic source XM211/taxon1888 match. This verifies native reference identity, not historical assay stocks, transcripts or constructs. reference https://www.uniprot.org/uniparc/UPI000247F579 evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes Retained exact271-residue archive has no active UniProtKB cross-reference. H6D580 is inactive and names ATCC21838/taxon1081613, not native XM211. Other inactive entries or different-taxon sequence matches do not override the native deposit. UniParc is not UniProtKB; this bounded archive result does not prove universal UniProt absence.
SlnM substrate, database example	is_database_example_substrate_of	MITE-reported double-bond and bis(spiroacetal) formation	MITE encodes a substrate example; its external identity remains ungrounded. No upstream reaction order, kinetic substrate preference or executable transformation rule is inferred from the example or SMARTS.	https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000441.json reference https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000441.json evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes MITE0000441 version 1, active, identifies SlnM/AEZ53956.1 and BGC0000144. The reaction description assigns 18,19-double-bond and bis(spiroacetal) formation, not ordinary O-methylation despite the enzyme family label. Heterologous, in-vitro, knockout and mutagenesis codes remain database assertions; both cited primary papers were inaccessible. No primary assay or native cofactor state is adopted.
MITE-reported double-bond and bis(spiroacetal) formation	has_database_example_product	salinomycin	Pinned MITE product matches full key KQXDHUJYNAXLNZ-SDCJTGBBSA-N in the retained repository-helper/RDKit2026.03.5 screen, with stereo_complete:false in source and owner. This is correspondence at incomplete stereo resolution, not fully resolved stereoisomer identity. The different full-key salinomycin-2 record is not merged or changed. No pathway finality or producer-grade upgrade; existing BGC_CHARACTERIZED/CLUSTER_DEMONSTRATED grades and all occurrences are preserved.	https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000441.json reference https://github.com/mite-standard/mite_data/blob/6eacd913b2036376031072f69cbb33908f132998/mite_data/data/MITE0000441.json evidence type DATABASE_ASSERTION retrieved on 2026-10-07 notes MITE0000441 version 1, active, identifies SlnM/AEZ53956.1 and BGC0000144. The reaction description assigns 18,19-double-bond and bis(spiroacetal) formation, not ordinary O-methylation despite the enzyme family label. Heterologous, in-vitro, knockout and mutagenesis codes remain database assertions; both cited primary papers were inaccessible. No primary assay or native cofactor state is adopted.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Explore across X-Mech

AntibioticMech (salinomycin) ↗ MediaIngredientMech (naturalproductmech:mibig-90cc844890) ↗ TaxonMech: Streptomyces albus (NCBITaxon:1888) ↗ PathwayMech (mibig:BGC0000144) ↗

Provenance

Source concept	Source	Version
BGC0000144	MIBIG	5

This page is generated from data/natural_products/polyketides/salinomycin.yaml, which is generated from the committed inventories. Neither is edited by hand.