NaturalProductMech

setomimycin

naturalproductmech:mibig-6f5a0ca9d2 MINTED SEEDED

Structure

Standard InChIKeyBIEJOJJMQZEKED-UHFFFAOYSA-N
SMILESCC1=CC(=O)C2=C(C3=C(C=CC=C3O)C(=C2C1C(=O)C)C4=C5C(C(CC(=O)C5=C(C6=C4C=CC=C6O)O)(C)O)C(=O)C)O
Stereochemistry undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-referencespubchem:198523

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Streptomyces aurantiacus JA 4570
NCBITaxon:1286094
SOURCE_ASSERTION mibig:BGC0002000 PMID:721705

Occurrences 3

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Streptomyces aurantiacus
NCBITaxon:47760
LOTUS DOI:10.1021/JA501630W
Streptomyces aurantiacus
NCBITaxon:47760
LOTUS DOI:10.7164/ANTIBIOTICS.31.1091
Streptomyces pseudovenezuelae
NCBITaxon:67350
LOTUS DOI:10.1021/JA501630W

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0002000 Streptomyces aurantiacus JA 4570
NCBITaxon:1286094
CLUSTER_UNSTATED genbank:NZ_AOPZ01000074.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Provenance

Source conceptSourceVersion
BGC0002000MIBIG4

This page is generated from data/natural_products/polyketides/setomimycin.yaml, which is generated from the committed inventories. Neither is edited by hand.