sorbicillin
naturalproductmech:mibig-d467c71634 MINTED SEEDED cytotoxic
Structure
| Standard InChIKey | RKKPUBAAIGFXOG-YTXTXJHMSA-N |
|---|---|
| SMILES | C/C=C/C=C/C(=O)C1=CC(=C(C(=C1O)C)O)C |
| Stereochemistry | fully defined |
| Cross-references | pubchem:5376187, npatlas:NPA024619 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Penicillium rubens Wisconsin 54-1255 NCBITaxon:500485 |
SOURCE_ASSERTION | mibig:BGC0001404 | DOI:10.3390/jof8010062 |
| Acremonium chrysogenum ATCC 11550 NCBITaxon:857340 |
SOURCE_ASSERTION | mibig:BGC0002190 | DOI:10.3390/molecules21060715 |
Occurrences 9
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Penicillium rubens NCBITaxon:1108849 |
LOTUS | DOI:10.1128/AEM.00350-16 |
| Huperzia serrata NCBITaxon:355589 |
LOTUS | DOI:10.1007/S10600-011-9991-4 |
| Penicillium terrestre NCBITaxon:374132 |
LOTUS | DOI:10.1016/J.TET.2011.08.037 |
| Streptomyces olivaceus NCBITaxon:47716 |
LOTUS | DOI:10.3390/MD17080442 |
| Acremonium chrysogenum NCBITaxon:5044 |
LOTUS | DOI:10.1007/S12010-019-02960-Z |
| Trichoderma NCBITaxon:5543 |
LOTUS | DOI:10.1248/CPB.57.220 |
| Trichoderma longibrachiatum NCBITaxon:5548 |
LOTUS | DOI:10.1139/V92-320 |
| Penicillium solitum NCBITaxon:60172 |
LOTUS | DOI:10.1016/J.TET.2011.08.037 |
| Plectris NCBITaxon:980945 |
LOTUS | DOI:10.1248/CPB.57.220 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001404 | Penicillium rubens Wisconsin 54-1255 NCBITaxon:500485 |
CLUSTER_UNSTATED | genbank:AM920436.1 |
| mibig:BGC0002190 | Acremonium chrysogenum ATCC 11550 NCBITaxon:857340 |
CLUSTER_UNSTATED | genbank:JPKY01000049.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 1
| Assay | Result | Reference |
|---|---|---|
| Fluorescence Cell-Based Primary HTS to Identify Reactive Oxygen Species Inducers in Cancer Cells Measured in Cell-Based System Using Plate Reader and Imaging Combination - 2044-01_Activator_SinglePoint_HTS_Activity | ACTIVE | pubchem.aid:624156 |
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0001404, BGC0002190. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001404 | MIBIG | 3 |
| BGC0002190 | MIBIG | 2 |
This page is generated from data/natural_products/polyketides/sorbicillin.yaml, which is generated from the committed inventories. Neither is edited by hand.