sorbicillin

naturalproductmech:mibig-d467c71634 MINTED SEEDED cytotoxic

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	RKKPUBAAIGFXOG-YTXTXJHMSA-N
SMILES	C/C=C/C=C/C(=O)C1=CC(=C(C(=C1O)C)O)C
Stereochemistry	fully defined
Cross-references	pubchem:5376187, npatlas:NPA024619

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 2

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Penicillium rubens Wisconsin 54-1255 NCBITaxon:500485	SOURCE_ASSERTION	mibig:BGC0001404	DOI:10.3390/jof8010062
Acremonium chrysogenum ATCC 11550 NCBITaxon:857340	SOURCE_ASSERTION	mibig:BGC0002190	DOI:10.3390/molecules21060715

Occurrences 9

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Penicillium rubens NCBITaxon:1108849	LOTUS	DOI:10.1128/AEM.00350-16
Huperzia serrata NCBITaxon:355589	LOTUS	DOI:10.1007/S10600-011-9991-4
Penicillium terrestre NCBITaxon:374132	LOTUS	DOI:10.1016/J.TET.2011.08.037
Streptomyces olivaceus NCBITaxon:47716	LOTUS	DOI:10.3390/MD17080442
Acremonium chrysogenum NCBITaxon:5044	LOTUS	DOI:10.1007/S12010-019-02960-Z
Trichoderma NCBITaxon:5543	LOTUS	DOI:10.1248/CPB.57.220
Trichoderma longibrachiatum NCBITaxon:5548	LOTUS	DOI:10.1139/V92-320
Penicillium solitum NCBITaxon:60172	LOTUS	DOI:10.1016/J.TET.2011.08.037
Plectris NCBITaxon:980945	LOTUS	DOI:10.1248/CPB.57.220

Biosynthetic gene clusters 2

Accession	Host	Locus evidence	Genome
mibig:BGC0001404	Penicillium rubens Wisconsin 54-1255 NCBITaxon:500485	CLUSTER_UNSTATED	genbank:AM920436.1
mibig:BGC0002190	Acremonium chrysogenum ATCC 11550 NCBITaxon:857340	CLUSTER_UNSTATED	genbank:JPKY01000049.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 1

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
Fluorescence Cell-Based Primary HTS to Identify Reactive Oxygen Species Inducers in Cancer Cells Measured in Cell-Based System Using Plate Reader and Imaging Combination - 2044-01_Activator_SinglePoint_HTS_Activity	ACTIVE	Not recorded	pubchem.aid:624156 assay Fluorescence Cell-Based Primary HTS to Identify Reactive Oxygen Species Inducers in Cancer Cells Measured in Cell-Based System Using Plate Reader and Imaging Combination - 2044-01_Activator_SinglePoint_HTS_Activity evidence reference pubchem.aid:624156 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 624156, deposited by Broad Institute; assay type Screening. call ACTIVE activity class CYTOTOXIC

Explore across X-Mech

AntibioticMech (sorbicillin) ↗ MediaIngredientMech (naturalproductmech:mibig-d467c71634) ↗ TaxonMech: Penicillium rubens Wisconsin 54-1255 (NCBITaxon:500485) ↗ TaxonMech: Acremonium chrysogenum ATCC 11550 (NCBITaxon:857340) ↗ PathwayMech (mibig:BGC0001404) ↗ PathwayMech (mibig:BGC0002190) ↗

Open questions 1

shared-structure — This structure is reported by more than one MIBiG entry: BGC0001404, BGC0002190. Confirm they describe the same compound rather than an upstream cross-reference error.

Provenance

Source concept	Source	Version
BGC0001404	MIBIG	3
BGC0002190	MIBIG	2

This page is generated from data/natural_products/polyketides/sorbicillin.yaml, which is generated from the committed inventories. Neither is edited by hand.