sporothriolide
CHEBI:141338 EXACT SEEDED antifungal
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A furofuran that is (3aR,6aR)-hexahydrofuro[3,4-b]furan substituted by an oxo group at positions 2 and 4, methylene group at position 3 and by an hexyl group at position 6. It is a metabolite isolated from several species of fungi.
Structure
| Standard InChIKey | AENZSPQGLJVLND-VWYCJHECSA-N |
|---|---|
| SMILES | CCCCCC[C@@H]1[C@H]2[C@H](C(=C)C(=O)O2)C(=O)O1 |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA017246, pubchem:10944473 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Hypomontagnella monticulosa NCBITaxon:2487000 |
SOURCE_ASSERTION | mibig:BGC0002262 | PMID:34123230 |
Occurrences 5
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Nodulisporium sp. A21 NCBITaxon:1647372 |
CHEBI | PMID:27017876 |
| Sporothrix sp. NCBITaxon:1902615 |
CHEBI | PMID:8119853 |
| Sporothrix NCBITaxon:29907 |
LOTUS | DOI:10.7164/ANTIBIOTICS.47.113 |
| Hypomontagnella monticulosa NCBITaxon:2487000 |
LOTUS | DOI:10.1021/ACS.JNATPROD.7B00714 |
| Hypoxylon monticulosum NCBITaxon:2487000 |
CHEBI | PMID:29043802 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002262 | Hypomontagnella monticulosa NCBITaxon:2487000 |
CLUSTER_UNSTATED | genbank:MT889334.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:141338 (same structure, same inchikey)
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002262 | MIBIG | 2 |
| CHEBI:141338 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/sporothriolide.yaml, which is generated from the committed inventories. Neither is edited by hand.