streptolydigin
CHEBI:45773 EXACT SEEDED antimicrobial unspecifiedenzyme inhibitor
A monocarboxylic acid amide that is a broad-spectrum antibiotic produced by Streptomyces lydicus.
Structure
| Standard InChIKey | KVTPRMVXYZKLIG-NCAOFHFGSA-N |
|---|---|
| SMILES | C[C@H]1[C@H]2C=C[C@@]3(CO3)[C@](O2)(O[C@@H]1[C@H](C)/C=C(\C)/C=C/C(=C\4/C(=O)[C@@H](N(C4=O)[C@@H]5CC[C@@H]([C@@H](O5)C)O)[C@H](C)C(=O)NC)/O)C |
| Stereochemistry | fully defined |
| Cross-references | pubchem:54708748 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, saccharide, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces lydicus NCBITaxon:47763 |
BGC_CHARACTERIZED | mibig:BGC0001046 | PMID:19875077 |
Occurrences 13
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces lydicus NCBITaxon:47763 |
CHEBI | 10.1021/ja107190w |
| Streptomyces lydicus NCBITaxon:47763 |
LOTUS | DOI:10.1007/S00253-009-1872-4 |
| Streptomyces lydicus NCBITaxon:47763 |
LOTUS | DOI:10.1007/S00253-013-4790-4 |
| Streptomyces lydicus NCBITaxon:47763 |
LOTUS | DOI:10.1007/S10295-013-1326-Y |
| Streptomyces lydicus NCBITaxon:47763 |
LOTUS | DOI:10.1021/JA00907A034 |
| Streptomyces lydicus NCBITaxon:47763 |
LOTUS | DOI:10.1021/JA107190W |
| Streptomyces lydicus NCBITaxon:47763 |
LOTUS | DOI:10.1038/JA.2012.37 |
| Streptomyces lydicus NCBITaxon:47763 |
LOTUS | DOI:10.1038/SREP44786 |
| Streptomyces lydicus NCBITaxon:47763 |
LOTUS | DOI:10.1099/MIC.0.061325-0 |
| Streptomyces lydicus NCBITaxon:47763 |
LOTUS | DOI:10.1111/J.1751-7915.2012.00352.X |
| Streptomyces lydicus NCBITaxon:47763 |
LOTUS | DOI:10.1128/AAC.01406-09 |
| Streptomyces lydicus NCBITaxon:47763 |
LOTUS | DOI:10.1128/JB.00108-11 |
| Streptomyces lydicus NCBITaxon:47763 |
LOTUS | DOI:10.7164/ANTIBIOTICS.36.1536 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001046 | Streptomyces lydicus NCBITaxon:47763 |
CLUSTER_DEMONSTRATED | genbank:FN433113.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 2
| Assay | Result | Reference |
|---|---|---|
| Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | KI 1.8 uM | PMID:16122422 |
| Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | KI 1.8 uM | PMID:16122422 |
Elsewhere in the fleet
- AntibioticMech — CHEBI:45773 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001046 | MIBIG | 5 |
| CHEBI:45773 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/streptolydigin.yaml, which is generated from the committed inventories. Neither is edited by hand.