tacrolimus
naturalproductmech:mibig-c60386127d MINTED SEEDED
Structure
| Standard InChIKey | QJJXYPPXXYFBGM-ONLNQCGCSA-N |
|---|---|
| SMILES | [H][C@]1(CC[C@@H](O)[C@@H](C1)OC)\C=C(/C)[C@@H]1OC(=O)[C@]2([H])CCCCN2C(=O)C(=O)[C@]2(O)O[C@@]([H])([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA019402 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. MA6548 NCBITaxon:82632 |
SOURCE_ASSERTION | mibig:BGC0000353 | PMID:9780228 |
Occurrences 0
None cited.
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000353 | Streptomyces sp. MA6548 NCBITaxon:82632 |
CLUSTER_UNSTATED | genbank:AF082100.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000353 | MIBIG | 5 |
This page is generated from data/natural_products/polyketides/tacrolimus.yaml, which is generated from the committed inventories. Neither is edited by hand.