tautomycetin

naturalproductmech:mibig-6dc5287e72 MINTED SEEDED enzyme inhibitor

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	VAIBGAONSFVVKI-CIFLJJJCSA-N
SMILES	CC/C(=C\C(=O)C[C@H](C)C[C@@H](C)CC[C@@H]([C@H](C)C(=O)C[C@H]([C@H](C)[C@@H](C)OC(=O)C[C@H](C1=C(C(=O)OC1=O)C)O)O)O)/C=C
Stereochemistry	fully defined
Cross-references	pubchem:16759609

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces griseochromogenes NCBITaxon:68214	BGC_CHARACTERIZED	mibig:BGC0000158	PMID:19191560

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces griseochromogenes NCBITaxon:68214	LOTUS	DOI:10.1021/NP8007478

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000158	Streptomyces griseochromogenes NCBITaxon:68214	CLUSTER_DEMONSTRATED	genbank:EU035755.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 12

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
Inhibitors of the vitamin D receptor (VDR): qHTS	OTHER 10 uM; NOT_DETERMINED	Not recorded	pubchem.aid:504847 assay Inhibitors of the vitamin D receptor (VDR): qHTS evidence reference pubchem.aid:504847 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504847, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001017535 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 10.0 units uM
Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2	OTHER 0.0224 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1479 assay Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 evidence reference pubchem.aid:1479 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1479, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001121649 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 0.0224 units uM
VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity	OTHER 0.0631 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2546 assay VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity evidence reference pubchem.aid:2546 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2546, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_035411 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 0.0631 units uM
qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2)	OTHER 2.8184 uM; NOT_DETERMINED	UniProtKB:O15296	pubchem.aid:881 assay qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) evidence reference pubchem.aid:881 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 881, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 2.8184 units uM target enzyme UniProtKB:O15296
qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1)	OTHER 3.5481 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1030 assay qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) evidence reference pubchem.aid:1030 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1030, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAP35567 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 3.5481 units uM
qHTS Assay for Inhibitors of GCN5L2	OTHER 3.1623 uM; ACTIVE	Not recorded	pubchem.aid:504327 assay qHTS Assay for Inhibitors of GCN5L2 evidence reference pubchem.aid:504327 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504327, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_066564 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 3.1623 units uM activity class ENZYME_INHIBITOR
qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)	OTHER 2.8184 uM; ACTIVE	Not recorded	pubchem.aid:894 assay qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) evidence reference pubchem.aid:894 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 894, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_000851 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 2.8184 units uM activity class ENZYME_INHIBITOR
qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent)	OTHER 8.9125 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1476 assay qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) evidence reference pubchem.aid:1476 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1476, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession 3I06_A was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 8.9125 units uM
qHTS for Inhibitors of Polymerase Kappa	OTHER 4.7444 uM; ACTIVE	Not recorded	pubchem.aid:588579 assay qHTS for Inhibitors of Polymerase Kappa evidence reference pubchem.aid:588579 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 588579, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_057302 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 4.7444 units uM activity class ENZYME_INHIBITOR
qHTS for Inhibitors of binding or entry into cells for Lassa Virus	OTHER 1.9953 uM; ACTIVE	Not recorded	pubchem.aid:720533 assay qHTS for Inhibitors of binding or entry into cells for Lassa Virus evidence reference pubchem.aid:720533 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 720533, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. call ACTIVE measurement type OTHER value 1.9953 units uM activity class ENZYME_INHIBITOR
qHTS for Inhibitors of binding or entry into cells for Marburg Virus	OTHER 2.5119 uM; ACTIVE	Not recorded	pubchem.aid:720532 assay qHTS for Inhibitors of binding or entry into cells for Marburg Virus evidence reference pubchem.aid:720532 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 720532, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession B45705 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 2.5119 units uM activity class ENZYME_INHIBITOR
qHTS for inhibitors of ROR gamma transcriptional activity	OTHER 0.5012 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2551 assay qHTS for inhibitors of ROR gamma transcriptional activity evidence reference pubchem.aid:2551 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2551, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_035411 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 0.5012 units uM

Explore across X-Mech

AntibioticMech (tautomycetin) ↗ MediaIngredientMech (naturalproductmech:mibig-6dc5287e72) ↗ TaxonMech: Streptomyces griseochromogenes (NCBITaxon:68214) ↗ PathwayMech (mibig:BGC0000158) ↗

Provenance

Source concept	Source	Version
BGC0000158	MIBIG	5

This page is generated from data/natural_products/polyketides/tautomycetin.yaml, which is generated from the committed inventories. Neither is edited by hand.