terreic acid

naturalproductmech:mibig-81dbb033ef MINTED SEEDED cytotoxicenzyme inhibitor

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	ATFNSNUJZOYXFC-RQJHMYQMSA-N
SMILES	[H][C@]12O[C@@]1([H])C(=O)C(O)=C(C)C2=O
Stereochemistry	fully defined
Cross-references	npatlas:NPA0714, pubchem:91437

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Aspergillus terreus NIH2624 NCBITaxon:341663	SOURCE_ASSERTION	mibig:BGC0000160	DOI:10.1177/1087057115625308

Occurrences 4

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Aspergillus terreus NCBITaxon:33178	LOTUS	DOI:10.1007/BF03178979
Aspergillus terreus NCBITaxon:33178	LOTUS	DOI:10.1021/JA01553A055
Aspergillus terreus NCBITaxon:33178	LOTUS	DOI:10.1021/OL502242A
Aspergillus flavipes NCBITaxon:41900	LOTUS	DOI:10.1039/P19720002071

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000160	Aspergillus terreus NIH2624 NCBITaxon:341663	CLUSTER_UNSTATED	genbank:CH476602.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 12

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization	OTHER 8.9125 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1463 assay Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization evidence reference pubchem.aid:1463 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1463, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 8.9125 units uM
Inhibitors of the vitamin D receptor (VDR): qHTS	OTHER 1.122 uM; NOT_DETERMINED	Not recorded	pubchem.aid:504847 assay Inhibitors of the vitamin D receptor (VDR): qHTS evidence reference pubchem.aid:504847 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504847, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001017535 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 1.122 units uM
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2	OTHER 50.1187 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1671190 assay Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2 evidence reference pubchem.aid:1671190 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1671190, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 50.1187 units uM
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2	OTHER 50.1187 uM; NOT_DETERMINED	UniProtKB:P18054	pubchem.aid:1671190 assay Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2 evidence reference pubchem.aid:1671190 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1671190, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. call NOT_DETERMINED measurement type OTHER value 50.1187 units uM target enzyme UniProtKB:P18054
qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase)	OTHER 56.2341 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1490 assay qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) evidence reference pubchem.aid:1490 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1490, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAG24257 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 56.2341 units uM
qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a	OTHER 22.3872 uM; NOT_DETERMINED	Not recorded	pubchem.aid:504332 assay qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a evidence reference pubchem.aid:504332 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504332, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession CAQ07474 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 22.3872 units uM
qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization	OTHER 19.9526 uM; ACTIVE	Not recorded	pubchem.aid:1468 assay qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization evidence reference pubchem.aid:1468 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1468, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession AAI14949 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 19.9526 units uM activity class ENZYME_INHIBITOR
qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding	OTHER 15.8489 uM; ACTIVE	Not recorded	pubchem.aid:1460 assay qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding evidence reference pubchem.aid:1460 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1460, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession AAI14949 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 15.8489 units uM activity class ENZYME_INHIBITOR
qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT	OTHER 20.5962 uM; NOT_DETERMINED	Not recorded	pubchem.aid:686978 assay qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT evidence reference pubchem.aid:686978 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 686978, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAI07878 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 20.5962 units uM
qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT	OTHER 18.3564 uM; NOT_DETERMINED	Not recorded	pubchem.aid:686979 assay qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT evidence reference pubchem.aid:686979 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 686979, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAI07878 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 18.3564 units uM
NCI In Vivo Anticancer Drug Screen. Data for tumor model Human Lung LX-1 Xenograft (intrarenal inoculation) in NU/NU Swiss (nude) mice	ACTIVE	Not recorded	pubchem.aid:264 assay NCI In Vivo Anticancer Drug Screen. Data for tumor model Human Lung LX-1 Xenograft (intrarenal inoculation) in NU/NU Swiss (nude) mice evidence reference pubchem.aid:264 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 264, deposited by DTP/NCI; assay type Other. call ACTIVE activity class CYTOTOXIC
NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line	ACTIVE	Not recorded	pubchem.aid:111 assay NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line evidence reference pubchem.aid:111 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 111, deposited by DTP/NCI; assay type Confirmatory. call ACTIVE activity class CYTOTOXIC

Explore across X-Mech

AntibioticMech (terreic acid) ↗ MediaIngredientMech (naturalproductmech:mibig-81dbb033ef) ↗ TaxonMech: Aspergillus terreus NIH2624 (NCBITaxon:341663) ↗ PathwayMech (mibig:BGC0000160) ↗

Provenance

Source concept	Source	Version
BGC0000160	MIBIG	3

This page is generated from data/natural_products/polyketides/terreic-acid.yaml, which is generated from the committed inventories. Neither is edited by hand.