terreic acid
naturalproductmech:mibig-81dbb033ef MINTED SEEDED cytotoxicenzyme inhibitor
Structure
| Standard InChIKey | ATFNSNUJZOYXFC-RQJHMYQMSA-N |
|---|---|
| SMILES | [H][C@]12O[C@@]1([H])C(=O)C(O)=C(C)C2=O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA0714, pubchem:91437 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Aspergillus terreus NIH2624 NCBITaxon:341663 |
SOURCE_ASSERTION | mibig:BGC0000160 | DOI:10.1177/1087057115625308 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Aspergillus terreus NCBITaxon:33178 |
LOTUS | DOI:10.1007/BF03178979 |
| Aspergillus terreus NCBITaxon:33178 |
LOTUS | DOI:10.1021/JA01553A055 |
| Aspergillus terreus NCBITaxon:33178 |
LOTUS | DOI:10.1021/OL502242A |
| Aspergillus flavipes NCBITaxon:41900 |
LOTUS | DOI:10.1039/P19720002071 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000160 | Aspergillus terreus NIH2624 NCBITaxon:341663 |
CLUSTER_UNSTATED | genbank:CH476602.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 12
| Assay | Result | Reference |
|---|---|---|
| Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization | 8.9125 uM | pubchem.aid:1463 |
| Inhibitors of the vitamin D receptor (VDR): qHTS | 1.122 uM | pubchem.aid:504847 |
| Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2 | 50.1187 uM | pubchem.aid:1671190 |
| Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2 | 50.1187 uM | pubchem.aid:1671190 |
| qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) | 56.2341 uM | pubchem.aid:1490 |
| qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a | 22.3872 uM | pubchem.aid:504332 |
| qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization | 19.9526 uM | pubchem.aid:1468 |
| qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding | 15.8489 uM | pubchem.aid:1460 |
| qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT | 20.5962 uM | pubchem.aid:686978 |
| qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT | 18.3564 uM | pubchem.aid:686979 |
| NCI In Vivo Anticancer Drug Screen. Data for tumor model Human Lung LX-1 Xenograft (intrarenal inoculation) in NU/NU Swiss (nude) mice | ACTIVE | pubchem.aid:264 |
| NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line | ACTIVE | pubchem.aid:111 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000160 | MIBIG | 3 |
This page is generated from data/natural_products/polyketides/terreic-acid.yaml, which is generated from the committed inventories. Neither is edited by hand.