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tetarimycin A

naturalproductmech:mibig-8a87fd1011 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyXQMPGQHPYUKJDG-UHFFFAOYSA-N
SMILESCC1=CC(O)=CC2=C1C(=O)C1=C(C2=O)C(C)(C)C2=CC(O)=CC(O)=C2C1=O
Stereochemistryfully defined
Cross-referencesnpatlas:NPA07518

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 0

None. The compound has a characterized gene cluster whose host NCBI does not name, which for an uncultured symbiont is the honest state — see the discussion below.

Occurrences 0

None cited.

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0000274 not named CLUSTER_DEMONSTRATED genbank:JX843821.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 0 producers (0 causal) 0 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT tetarimycin A naturalproductmech:mibig-8a87fd1011 Polyketides TARGETS & BIOACTIVITY 0 molecular targets 0 bioactivities · 0 graphs

Explore across X-Mech

AntibioticMech (tetarimycin A) ↗ MediaIngredientMech (naturalproductmech:mibig-8a87fd1011) ↗ PathwayMech (mibig:BGC0000274) ↗

Open questions 1

unnamed-producer — No producer claim is written from BGC0000274, which gives NCBITaxon:77133 (uncultured bacterium — shared by every unplaced bacterium), because the taxon names no single organism. The cluster is kept: a characterized locus is an origin assertion whether or not its host has a name, and for a compound from an uncultured symbiont that is the honest state. Name the producer if the primary literature does.

Provenance

Source conceptSourceVersion
BGC0000274MIBIG5

This page is generated from data/natural_products/polyketides/tetarimycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.