thioangucycline B
naturalproductmech:mibig-97792c7fb9 MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | HKMDGBLVBSZZGX-QANDYNDUSA-N |
|---|---|
| SMILES | COC1=CC=CC2=C1[C@@H](O)C1=C(SC3=C4C(=C5C(=O)C[C@](C)(O)CC5=C3)[C@@H](O)C3=C(C(OC)=CC=C3)[C@H]4O)C=C3C[C@@](C)(O)CC(=O)C3=C1C2=O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA033239 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. CB00072 NCBITaxon:1703928 |
BGC_CHARACTERIZED | mibig:BGC0002477 | PMID:33465268 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1002/ANIE.202015570 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002477 | Streptomyces sp. CB00072 NCBITaxon:1703928 |
CLUSTER_DEMONSTRATED | genbank:LIPB01000001.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002477 | MIBIG | 3 |
This page is generated from data/natural_products/polyketides/thioangucycline-b.yaml, which is generated from the committed inventories. Neither is edited by hand.