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tiacumicin B

naturalproductmech:mibig-f6f3e2e074 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyZVGNESXIJDCBKN-UUEYKCAUSA-N
SMILES[H][C@]1(C\C=C(/C)\C=C(C)\[C@]([H])(O[C@@H]2OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]2O)[C@@H](CC)\C=C(C)\[C@@H](O)C\C=C\C=C(CO[C@@H]2O[C@H](C)[C@@H](OC(=O)C3=C(O)C(Cl)=C(O)C(Cl)=C3CC)[C@H](O)[C@@H]2OC)\C(=O)O1)[C@@H](C)O
Stereochemistryfully defined
Cross-referencesnpatlas:NPA03282, pubchem:70678896

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Dactylosporangium aurantiacum subsp. hamdenensis
NCBITaxon:703577		 BGC_CHARACTERIZED mibig:BGC0000165 DOI:10.1021/ja109445q

Occurrences 5

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Actinoplanes deccanensis
NCBITaxon:113561		 LOTUS DOI:10.1039/P19870001353
Micromonospora echinospora
NCBITaxon:1877		 LOTUS DOI:10.7164/ANTIBIOTICS.39.1407
Dactylosporangium aurantiacum
NCBITaxon:35754		 LOTUS DOI:10.1080/01483919808068322
Dactylosporangium aurantiacum
NCBITaxon:35754		 LOTUS DOI:10.7164/ANTIBIOTICS.40.567
Dactylosporangium aurantiacum
NCBITaxon:35754		 LOTUS DOI:10.7164/ANTIBIOTICS.40.575

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0000165 Dactylosporangium aurantiacum subsp. hamdenensis
NCBITaxon:703577 		CLUSTER_DEMONSTRATED genbank:HQ011923.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (1 causal) 5 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT tiacumicin B naturalproductmech:mibig-f6f3e2e074 Polyketides TARGETS & BIOACTIVITY 0 molecular targets 0 bioactivities · 0 graphs

Explore across X-Mech

AntibioticMech (tiacumicin B) ↗ MediaIngredientMech (naturalproductmech:mibig-f6f3e2e074) ↗ TaxonMech: Dactylosporangium aurantiacum subsp. hamdenensis (NCBITaxon:703577) ↗ PathwayMech (mibig:BGC0000165) ↗

Provenance

Source conceptSourceVersion
BGC0000165MIBIG4

This page is generated from data/natural_products/polyketides/tiacumicin-b.yaml, which is generated from the committed inventories. Neither is edited by hand.