tiacumicin B
naturalproductmech:mibig-f6f3e2e074 MINTED SEEDED
Structure
| Standard InChIKey | ZVGNESXIJDCBKN-UUEYKCAUSA-N |
|---|---|
| SMILES | [H][C@]1(C\C=C(/C)\C=C(C)\[C@]([H])(O[C@@H]2OC(C)(C)[C@@H](OC(=O)C(C)C)[C@H](O)[C@@H]2O)[C@@H](CC)\C=C(C)\[C@@H](O)C\C=C\C=C(CO[C@@H]2O[C@H](C)[C@@H](OC(=O)C3=C(O)C(Cl)=C(O)C(Cl)=C3CC)[C@H](O)[C@@H]2OC)\C(=O)O1)[C@@H](C)O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA03282, pubchem:70678896 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Dactylosporangium aurantiacum subsp. hamdenensis NCBITaxon:703577 |
BGC_CHARACTERIZED | mibig:BGC0000165 | DOI:10.1021/ja109445q |
Occurrences 5
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Actinoplanes deccanensis NCBITaxon:113561 |
LOTUS | DOI:10.1039/P19870001353 |
| Micromonospora echinospora NCBITaxon:1877 |
LOTUS | DOI:10.7164/ANTIBIOTICS.39.1407 |
| Dactylosporangium aurantiacum NCBITaxon:35754 |
LOTUS | DOI:10.1080/01483919808068322 |
| Dactylosporangium aurantiacum NCBITaxon:35754 |
LOTUS | DOI:10.7164/ANTIBIOTICS.40.567 |
| Dactylosporangium aurantiacum NCBITaxon:35754 |
LOTUS | DOI:10.7164/ANTIBIOTICS.40.575 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000165 | Dactylosporangium aurantiacum subsp. hamdenensis NCBITaxon:703577 |
CLUSTER_DEMONSTRATED | genbank:HQ011923.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000165 | MIBIG | 4 |
This page is generated from data/natural_products/polyketides/tiacumicin-b.yaml, which is generated from the committed inventories. Neither is edited by hand.