tirandamycin
naturalproductmech:mibig-1acf40c3b8 MINTED SEEDED
Structure
| Standard InChIKey | QAJQBKCKMWVTHU-XLUDVLRBSA-N |
|---|---|
| SMILES | C[C@H]1[C@@H]2C(=O)[C@H]3[C@](O3)([C@@](O2)(O[C@@H]1[C@H](C)/C=C(\C)/C=C/C(=O)C4=C(NCC4=O)O)C)C |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA017695 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces sp. 307-9 NCBITaxon:529089 |
SOURCE_ASSERTION | mibig:BGC0001052 | PMID:20127927 |
Occurrences 7
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1002/CBIC.200900658 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1016/J.BBRC.2011.02.040 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1021/NP9005597 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1021/OL200420U |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1038/S41429-018-0103-6 |
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.3389/FMICB.2019.00482 |
| Streptomyces flaveolus NCBITaxon:67297 |
LOTUS | DOI:10.1021/JA00748A067 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001052 | Streptomyces sp. 307-9 NCBITaxon:529089 |
CLUSTER_DEMONSTRATED | genbank:GU385216.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001052 | MIBIG | 5 |
This page is generated from data/natural_products/polyketides/tirandamycin.yaml, which is generated from the committed inventories. Neither is edited by hand.