tylactone
naturalproductmech:mibig-08c35872c0 MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | YJSXTLYNFBFHAT-OPSQKTBLSA-N |
|---|---|
| SMILES | CC[C@@H]1C[C@H](C(=O)/C=C/C(=C/[C@H]([C@H](OC(=O)C[C@H]([C@H]([C@H]1O)C)O)CC)C)/C)C |
| Stereochemistry | fully defined |
| Cross-references | pubchem:12782930 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces fradiae NCBITaxon:1906 |
SOURCE_ASSERTION | mibig:BGC0000166 | PMID:18693734 |
| Micromonospora chalcea subsp. izumensis NCBITaxon:2008351 |
SOURCE_ASSERTION | mibig:BGC0001812 | PMID:28525276 |
Occurrences 0
None cited.
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000166 | Streptomyces fradiae NCBITaxon:1906 |
CLUSTER_UNSTATED | genbank:U78289.1 |
| mibig:BGC0001812 | Micromonospora chalcea subsp. izumensis NCBITaxon:2008351 |
CLUSTER_UNSTATED | genbank:MF033535.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000166, BGC0001812. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000166 | MIBIG | 5 |
| BGC0001812 | MIBIG | 3 |
This page is generated from data/natural_products/polyketides/tylactone.yaml, which is generated from the committed inventories. Neither is edited by hand.