uncialamycin
naturalproductmech:mibig-9ecbc5f416 MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | OBGWIHKWGGEOEV-YFRVKLFPSA-N |
|---|---|
| SMILES | CC(O)[C@@]12O[C@@]11[C@H](O)C#C\C=C/C#C[C@@H]2NC2=C1C=C(O)C1=C2C(=O)C2=CC=CC=C2C1=O |
| Stereochemistry | undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers |
| Cross-references | npatlas:NPA01771, pubchem:16744765 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces uncialis NCBITaxon:1048205 |
SOURCE_ASSERTION | mibig:BGC0001377 | PMID:25019332 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces uncialis NCBITaxon:1048205 |
LOTUS | DOI:10.1021/OL052081F |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001377 | Streptomyces uncialis NCBITaxon:1048205 |
CLUSTER_UNSTATED | genbank:KT762610.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
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Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001377 | MIBIG | 5 |
This page is generated from data/natural_products/polyketides/uncialamycin.yaml, which is generated from the committed inventories. Neither is edited by hand.