6-methylsalicylic acid
CHEBI:17637 EXACT SEEDED
A monohydroxybenzoic acid that is salicylic acid in which the hydrogen ortho to the carboxylic acid group is substituted by a methyl group.
Structure
| Standard InChIKey | HCJMNOSIAGSZBM-UHFFFAOYSA-N |
|---|---|
| SMILES | CC1=C(C(=CC=C1)O)C(=O)O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:11279 |
Filing pathway
Shikimates and phenylpropanoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Glarea lozoyensis NCBITaxon:101852 |
SOURCE_ASSERTION | mibig:BGC0001275 | PMID:15800788 |
| Aspergillus terreus NCBITaxon:33178 |
SOURCE_ASSERTION | mibig:BGC0001276 | PMID:9003280 |
Occurrences 25
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Mutisia spinosa NCBITaxon:130278 |
LOTUS | DOI:10.1016/S0031-9422(00)85512-0 |
| Mycobacterium phlei NCBITaxon:1771 |
LOTUS | DOI:10.1021/BI00822A018 |
| Neolentinus cyathiformis NCBITaxon:182019 |
LOTUS | DOI:10.3891/ACTA.CHEM.SCAND.20-0045 |
| Streptomyces albidoflavus NCBITaxon:1886 |
LOTUS | DOI:10.1128/JB.177.15.4544-4548.1995 |
| Streptomyces coelicolor NCBITaxon:1902 |
LOTUS | DOI:10.1128/JB.177.15.4544-4548.1995 |
| Streptomyces viridochromogenes NCBITaxon:1938 |
LOTUS | DOI:10.1128/JB.177.15.4544-4548.1995 |
| Geosmithia langdonii NCBITaxon:240214 |
LOTUS | DOI:10.1021/NP5000473 |
| Penicillium vulpinum NCBITaxon:29845 |
LOTUS | DOI:10.3987/COM-98-8253 |
| Tetramorium impurum NCBITaxon:30205 |
LOTUS | DOI:10.1007/BF00368520 |
| Phoma NCBITaxon:37463 |
LOTUS | DOI:10.1021/NP50083A013 |
| Leibnitzia anandria NCBITaxon:41596 |
LOTUS | DOI:10.3390/MOLECULES19044046 |
| Leibnitzia anandria NCBITaxon:41596 |
CHEBI | PMID:24699147 |
| Aspergillus flavipes NCBITaxon:41900 |
LOTUS | DOI:10.1186/2191-2858-2-9 |
| Lasiodiplodia theobromae NCBITaxon:45133 |
LOTUS | DOI:10.1016/J.TET.2009.10.084 |
| Penicillium griseofulvum NCBITaxon:5078 |
LOTUS | DOI:10.1039/C39840001005 |
| Penicillium griseofulvum NCBITaxon:5078 |
LOTUS | DOI:10.1128/AEM.41.6.1407-1412.1981 |
| Penicillium griseofulvum NCBITaxon:5078 |
CHEBI | PMID:16345795 |
| Garcinia mangostana NCBITaxon:58228 |
LOTUS | DOI:10.1016/J.PHYTOL.2012.11.007 |
| Penicillium solitum NCBITaxon:60172 |
LOTUS | DOI:10.1016/S0021-9673(01)89440-1 |
| Aspergillus fumigatus NCBITaxon:746128 |
LOTUS | DOI:10.1042/BJ0970321 |
| Epicoccum sorghinum NCBITaxon:749593 |
LOTUS | DOI:10.1080/00275514.1992.12026197 |
| Epicoccum sorghinum NCBITaxon:749593 |
LOTUS | DOI:10.2307/3760381 |
| Camponotus vagus NCBITaxon:84551 |
LOTUS | DOI:10.1016/0305-0491(87)90286-0 |
| Glarea lozoyensis NCBITaxon:101852 |
LOTUS | DOI:10.1007/S00438-005-1132-Y |
| Aspergillus terreus NCBITaxon:33178 |
LOTUS | DOI:10.1007/S004380050289 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001275 | Glarea lozoyensis NCBITaxon:101852 |
CLUSTER_UNSTATED | genbank:AY941322.1 |
| mibig:BGC0001276 | Aspergillus terreus NCBITaxon:33178 |
CLUSTER_UNSTATED | genbank:D85860.2 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 2
name-disagreement — ChEBI calls this structure '6-methylsalicylic acid' and MIBiG calls it '6-methylsalicyclic acid'. They share a Standard InChIKey, so if the names denote different compounds then one upstream record has the wrong structure. Check which.
shared-structure — This structure is reported by more than one MIBiG entry: BGC0001275, BGC0001276. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001275 | MIBIG | 3 |
| BGC0001276 | MIBIG | 3 |
| CHEBI:17637 | CHEBI | 3-star |
This page is generated from data/natural_products/shikimates_and_phenylpropanoids/6-methylsalicylic-acid.yaml, which is generated from the committed inventories. Neither is edited by hand.