aspulvinone E
CHEBI:17704 EXACT SEEDED antiviral
A 4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one in which the double bond adopts a Z-configuration. It is a marine metabolite isolated from the fungus Aspergillus terreus and exhibits antiviral activity.
Structure
| Standard InChIKey | BNNVVTQUWNGKPH-ZROIWOOFSA-N |
|---|---|
| SMILES | C1=CC(=CC=C1/C=C\2/C(=C(C(=O)O2)C3=CC=C(C=C3)O)O)O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA001618 |
Filing pathway
Shikimates and phenylpropanoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is nrps, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Aspergillus terreus NIH2624 NCBITaxon:341663 |
BGC_CHARACTERIZED | mibig:BGC0002348 | DOI:10.1039/d2ra08133d |
Occurrences 8
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Aspergillus terreus NCBITaxon:33178 |
CHEBI | 10.1007/s00044-014-1164-0 |
| Aspergillus terreus NCBITaxon:33178 |
LOTUS | DOI:10.1016/0031-9422(73)80469-8 |
| Aspergillus terreus NCBITaxon:33178 |
LOTUS | DOI:10.1016/J.BMCL.2013.01.051 |
| Aspergillus terreus NCBITaxon:33178 |
LOTUS | DOI:10.1016/J.CHEMBIOL.2016.03.014 |
| Aspergillus terreus NCBITaxon:33178 |
LOTUS | DOI:10.1016/J.PHYTOL.2015.02.009 |
| Aspergillus terreus NCBITaxon:33178 |
CHEBI | PMID:23411074 |
| Aspergillus flavipes NCBITaxon:41900 |
LOTUS | DOI:10.1186/2191-2858-2-9 |
| Aspergillus NCBITaxon:5052 |
LOTUS | DOI:10.1021/ACS.JNATPROD.6B00878 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0002348 | Aspergillus terreus NIH2624 NCBITaxon:341663 |
CLUSTER_DEMONSTRATED | genbank:CH476597.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:17704 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0002348 | MIBIG | 2 |
| CHEBI:17704 | CHEBI | 3-star |
This page is generated from data/natural_products/shikimates_and_phenylpropanoids/aspulvinone-e.yaml, which is generated from the committed inventories. Neither is edited by hand.