chartreusin
naturalproductmech:mibig-178140d34c MINTED SEEDED enzyme inhibitor
Structure
| Standard InChIKey | PONPPNYZKHNPKZ-RYBWXQSLSA-N |
|---|---|
| SMILES | C[C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)OC2=CC=CC3=C2C4=C5C6=C(C=CC(=C6C(=O)O4)C)OC(=O)C5=C3O)O[C@@H]7[C@@H]([C@H]([C@H]([C@H](O7)C)O)OC)O)O)O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:5281394 |
Filing pathway
Shikimates and phenylpropanoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces chartreusis NCBITaxon:1969 |
SOURCE_ASSERTION | mibig:BGC0000207 | PMID:15911378 |
Occurrences 6
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces chartreusis NCBITaxon:1969 |
LOTUS | DOI:10.1002/JOBM.3630160704 |
| Streptomyces chartreusis NCBITaxon:1969 |
LOTUS | DOI:10.1002/JOBM.3630170308 |
| Streptomyces chartreusis NCBITaxon:1969 |
LOTUS | DOI:10.1128/AAC.12.5.571 |
| Streptomyces chartreusis NCBITaxon:1969 |
LOTUS | DOI:10.3390/MD15080244 |
| Streptomyces chartreusis NCBITaxon:1969 |
LOTUS | DOI:10.7164/ANTIBIOTICS.46.1611 |
| Streptomyces chartreusis NCBITaxon:1969 |
LOTUS | DOI:10.7164/ANTIBIOTICS.47.655 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000207 | Streptomyces chartreusis NCBITaxon:1969 |
CLUSTER_UNSTATED | genbank:AJ786383.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 12
| Assay | Result | Reference |
|---|---|---|
| HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails | 100 uM | pubchem.aid:540317 |
| Nrf2 qHTS screen for inhibitors | 18.3564 uM | pubchem.aid:504444 |
| VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity | 35.4813 uM | pubchem.aid:2546 |
| qHTS Assay for Identification of Novel General Anesthetics | 35.4813 uM | pubchem.aid:485281 |
| qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide | 28.1838 uM | pubchem.aid:1766 |
| qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide | 28.1838 uM | pubchem.aid:1766 |
| qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia | 7.0627 uM | pubchem.aid:2451 |
| qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). | 10 uM | pubchem.aid:588795 |
| qHTS for Inhibitors of Polymerase Iota | 19.9526 uM | pubchem.aid:588590 |
| qHTS for Inhibitors of Polymerase Kappa | 35.4813 uM | pubchem.aid:588579 |
| qHTS for inhibitors of ROR gamma transcriptional activity | 11.2202 uM | pubchem.aid:2551 |
| qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen | ACTIVE | pubchem.aid:2472 |
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000207 | MIBIG | 5 |
This page is generated from data/natural_products/shikimates_and_phenylpropanoids/chartreusin.yaml, which is generated from the committed inventories. Neither is edited by hand.