chartreusin

naturalproductmech:mibig-178140d34c MINTED SEEDED enzyme inhibitor

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	PONPPNYZKHNPKZ-RYBWXQSLSA-N
SMILES	C[C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)OC2=CC=CC3=C2C4=C5C6=C(C=CC(=C6C(=O)O4)C)OC(=O)C5=C3O)O[C@@H]7[C@@H]([C@H]([C@H]([C@H](O7)C)O)OC)O)O)O
Stereochemistry	fully defined
Cross-references	pubchem:5281394

Filing pathway

Shikimates and phenylpropanoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces chartreusis NCBITaxon:1969	SOURCE_ASSERTION	mibig:BGC0000207	PMID:15911378

Occurrences 6

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces chartreusis NCBITaxon:1969	LOTUS	DOI:10.1002/JOBM.3630160704
Streptomyces chartreusis NCBITaxon:1969	LOTUS	DOI:10.1002/JOBM.3630170308
Streptomyces chartreusis NCBITaxon:1969	LOTUS	DOI:10.1128/AAC.12.5.571
Streptomyces chartreusis NCBITaxon:1969	LOTUS	DOI:10.3390/MD15080244
Streptomyces chartreusis NCBITaxon:1969	LOTUS	DOI:10.7164/ANTIBIOTICS.46.1611
Streptomyces chartreusis NCBITaxon:1969	LOTUS	DOI:10.7164/ANTIBIOTICS.47.655

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0000207	Streptomyces chartreusis NCBITaxon:1969	CLUSTER_UNSTATED	genbank:AJ786383.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 12

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails	OTHER 100 uM; INACTIVE	Not recorded	pubchem.aid:540317 assay HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails evidence reference pubchem.aid:540317 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 540317, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_001120700 was left ungrounded because PubChem did not provide a UniProtKB accession. call INACTIVE measurement type OTHER value 100.0 units uM
Nrf2 qHTS screen for inhibitors	OTHER 18.3564 uM; NOT_DETERMINED	Not recorded	pubchem.aid:504444 assay Nrf2 qHTS screen for inhibitors evidence reference pubchem.aid:504444 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 504444, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_001138884 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 18.3564 units uM
VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity	OTHER 35.4813 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2546 assay VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity evidence reference pubchem.aid:2546 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2546, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_035411 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 35.4813 units uM
qHTS Assay for Identification of Novel General Anesthetics	OTHER 35.4813 uM; INACTIVE	Not recorded	pubchem.aid:485281 assay qHTS Assay for Identification of Novel General Anesthetics evidence reference pubchem.aid:485281 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 485281, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession 3F32_A was left ungrounded because PubChem did not provide a UniProtKB accession. call INACTIVE measurement type OTHER value 35.4813 units uM
qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide	OTHER 28.1838 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1766 assay qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide evidence reference pubchem.aid:1766 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1766, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_000235 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 28.1838 units uM
qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide	OTHER 28.1838 uM; NOT_DETERMINED	Not recorded	pubchem.aid:1766 assay qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide evidence reference pubchem.aid:1766 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1766, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_005924 was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 28.1838 units uM
qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia	OTHER 7.0627 uM; NOT_DETERMINED	Not recorded	pubchem.aid:2451 assay qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia evidence reference pubchem.aid:2451 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2451, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession 2ISV_A was left ungrounded because PubChem did not provide a UniProtKB accession. call NOT_DETERMINED measurement type OTHER value 7.0627 units uM
qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1).	OTHER 10 uM; ACTIVE	Not recorded	pubchem.aid:588795 assay qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). evidence reference pubchem.aid:588795 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 588795, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_004102 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 10.0 units uM activity class ENZYME_INHIBITOR
qHTS for Inhibitors of Polymerase Iota	OTHER 19.9526 uM; ACTIVE	Not recorded	pubchem.aid:588590 assay qHTS for Inhibitors of Polymerase Iota evidence reference pubchem.aid:588590 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 588590, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_009126 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 19.9526 units uM activity class ENZYME_INHIBITOR
qHTS for Inhibitors of Polymerase Kappa	OTHER 35.4813 uM; ACTIVE	Not recorded	pubchem.aid:588579 assay qHTS for Inhibitors of Polymerase Kappa evidence reference pubchem.aid:588579 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 588579, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_057302 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 35.4813 units uM activity class ENZYME_INHIBITOR
qHTS for inhibitors of ROR gamma transcriptional activity	OTHER 11.2202 uM; ACTIVE	Not recorded	pubchem.aid:2551 assay qHTS for inhibitors of ROR gamma transcriptional activity evidence reference pubchem.aid:2551 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2551, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_035411 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE measurement type OTHER value 11.2202 units uM activity class ENZYME_INHIBITOR
qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen	ACTIVE	Not recorded	pubchem.aid:2472 assay qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen evidence reference pubchem.aid:2472 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 2472, deposited by NCGC; assay type Screening. Target accession NP_002037 was left ungrounded because PubChem did not provide a UniProtKB accession. call ACTIVE activity class ENZYME_INHIBITOR

Explore across X-Mech

AntibioticMech (chartreusin) ↗ MediaIngredientMech (naturalproductmech:mibig-178140d34c) ↗ TaxonMech: Streptomyces chartreusis (NCBITaxon:1969) ↗ PathwayMech (mibig:BGC0000207) ↗

Provenance

Source concept	Source	Version
BGC0000207	MIBIG	5

This page is generated from data/natural_products/shikimates_and_phenylpropanoids/chartreusin.yaml, which is generated from the committed inventories. Neither is edited by hand.