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2-cis-abscisic acid

CHEBI:22152 EXACT SEEDED

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

A member of the class of abscisic acids in which the double bond betweeen positions 2 and 3 has cis- (natural) geometry.

Structure

Standard InChIKeyJLIDBLDQVAYHNE-LXGGSRJLSA-N
SMILESCC1=CC(=O)CC(C1(/C=C/C(=C\C(=O)O)/C)O)(C)C
Stereochemistry undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-referencespubchem:5375199

Filing pathway

Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Leptosphaeria maculans JN3
NCBITaxon:985895		 SOURCE_ASSERTION mibig:BGC0001899 PMID:31034868

Occurrences 3

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Axinella polypoides
NCBITaxon:12959		 LOTUS DOI:10.1016/J.BCP.2011.06.042
Botrytis cinerea
NCBITaxon:40559		 LOTUS DOI:10.1111/1462-2920.14258
Leptosphaeria maculans
NCBITaxon:5022		 LOTUS DOI:10.1016/J.FGB.2019.04.015

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0001899 Leptosphaeria maculans JN3
NCBITaxon:985895 		CLUSTER_UNSTATED genbank:FP929136.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (0 causal) 3 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 0 curated pathway steps NATURAL PRODUCT 2-cis-abscisic acid CHEBI:22152 Terpenoids TARGETS & BIOACTIVITY 0 molecular targets 15 bioactivities · 0 graphs

Bioactivities 15

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

AssayResultTarget enzymeSource detail
Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assayOTHER 6.7823 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1963593
assay
Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
evidence
  • reference
    pubchem.aid:1963593
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963593, deposited by 824; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
6.7823
units
uM
Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assayOTHER 6.7823 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1963593
assay
Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay
evidence
  • reference
    pubchem.aid:1963593
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963593, deposited by 824; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_000015 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
6.7823
units
uM
Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay: SummaryOTHER 0.302955 uM; NOT_DETERMINEDNot recorded
pubchem.aid:2061107
assay
Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay: Summary
evidence
  • reference
    pubchem.aid:2061107
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2061107, deposited by 824; assay type Summary. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
0.302955
units
uM
Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay: SummaryOTHER 0.302955 uM; NOT_DETERMINEDNot recorded
pubchem.aid:2061107
assay
Adrenergic beta2 receptor (ADRB2) small molecule agonists, cell-based qHTS assay: Summary
evidence
  • reference
    pubchem.aid:2061107
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 2061107, deposited by 824; assay type Summary. Source outcome: Inconclusive. Source endpoint: Potency. Target accession NP_000015 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
0.302955
units
uM
Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: luciferase reporter qHTS assayOTHER 62.5906 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1671199
assay
Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: luciferase reporter qHTS assay
evidence
  • reference
    pubchem.aid:1671199
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1671199, deposited by 824; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
62.5906
units
uM
Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: luciferase reporter qHTS assayOTHER 62.5906 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1671199
assay
Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: luciferase reporter qHTS assay
evidence
  • reference
    pubchem.aid:1671199
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1671199, deposited by 824; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession EAW99313 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
62.5906
units
uM
cAMP Responsive Elements (CRE) small molecule antagonists, cell-based qHTS assayOTHER 0.0017 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1963591
assay
cAMP Responsive Elements (CRE) small molecule antagonists, cell-based qHTS assay
evidence
  • reference
    pubchem.aid:1963591
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963591, deposited by 824; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
0.0017
units
uM
cAMP Responsive Elements (CRE) small molecule antagonists, cell-based qHTS assayOTHER 0.0017 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1963591
assay
cAMP Responsive Elements (CRE) small molecule antagonists, cell-based qHTS assay
evidence
  • reference
    pubchem.aid:1963591
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1963591, deposited by 824; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAV38316 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
0.0017
units
uM
qHTS Assay for Agonists of the Thyroid Stimulating Hormone ReceptorOTHER 0.0316 uM; NOT_DETERMINEDNot recorded
pubchem.aid:926
assay
qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor
evidence
  • reference
    pubchem.aid:926
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 926, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAR07906 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
0.0316
units
uM
qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293OTHER 0.0316 uM; INACTIVENot recorded
pubchem.aid:938
assay
qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293
evidence
  • reference
    pubchem.aid:938
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 938, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession AAR07906 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
INACTIVE
measurement type
OTHER
value
0.0316
units
uM
qHTS assay for small molecule agonists of estrogen receptor alpha signalingOTHER 39.8107 uM; NOT_DETERMINEDNot recorded
pubchem.aid:588514
assay
qHTS assay for small molecule agonists of estrogen receptor alpha signaling
evidence
  • reference
    pubchem.aid:588514
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 588514, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AEP43755 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
39.8107
units
uM
qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathwayOTHER 37.578 uM; ACTIVENot recorded
pubchem.aid:651741
assay
qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway
evidence
  • reference
    pubchem.aid:651741
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 651741, deposited by NCGC; assay type Confirmatory. Source endpoint: Potency. Target accession NP_006155 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
ACTIVE
measurement type
OTHER
value
37.578
units
uM
qHTS assay for small molecule antagonists of androgen receptor signalingOTHER 0.631 uM; NOT_DETERMINEDNot recorded
pubchem.aid:588516
assay
qHTS assay for small molecule antagonists of androgen receptor signaling
evidence
  • reference
    pubchem.aid:588516
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 588516, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAI32976 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
0.631
units
uM
qHTS assay to identify small molecule agonists of the endoplasmic reticulum stress response signaling pathway - cell viability counter screenOTHER 17.187 uM; NOT_DETERMINEDNot recorded
pubchem.aid:1159517
assay
qHTS assay to identify small molecule agonists of the endoplasmic reticulum stress response signaling pathway - cell viability counter screen
evidence
  • reference
    pubchem.aid:1159517
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 1159517, deposited by 824; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency.
call
NOT_DETERMINED
measurement type
OTHER
value
17.187
units
uM
qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretionOTHER 74.978 uM; NOT_DETERMINEDNot recorded
pubchem.aid:651758
assay
qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion
evidence
  • reference
    pubchem.aid:651758
    evidence type
    DATABASE_ASSERTION
    notes
    PubChem BioAssay AID 651758, deposited by NCGC; assay type Confirmatory. Source outcome: Inconclusive. Source endpoint: Potency. Target accession AAA59158 was left ungrounded because PubChem did not provide a UniProtKB accession.
call
NOT_DETERMINED
measurement type
OTHER
value
74.978
units
uM

Explore across X-Mech

AntibioticMech (2-cis-abscisic acid) ↗ MediaIngredientMech (CHEBI:22152) ↗ TaxonMech: Leptosphaeria maculans JN3 (NCBITaxon:985895) ↗ PathwayMech (mibig:BGC0001899) ↗

Open questions 1

name-disagreement — ChEBI calls this structure '2-cis-abscisic acid' and MIBiG calls it 'abscisic acid'. They share a Standard InChIKey, so if the names denote different compounds then one upstream record has the wrong structure. Check which.

Provenance

Source conceptSourceVersion
BGC0001899MIBIG3
CHEBI:22152CHEBI3-star

This page is generated from data/natural_products/terpenoids/2-cis-abscisic-acid.yaml, which is generated from the committed inventories. Neither is edited by hand.