NaturalProductMech

(+)-(2S,3R,9R)-pristinol

CHEBI:138165 EXACT SEEDED

A bicyclic sesquiterpenoid that is 2,3,5,6,7,8,9,9a-octahydro-1H-cyclopenta[8]annulen-6-ol carrying four additional methyl substiuents at positions 1, 4, 8 and 8.

Structure

Standard InChIKeyPXKJCWZAMAFFIW-GLBIRDDMSA-N
SMILESC[C@@H]1CC/C/2=C(/C[C@@H](CC(C[C@@H]12)(C)C)O)\C
Stereochemistryfully defined

Filing pathway

Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is terpene, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Streptomyces pristinaespiralis ATCC 25486
NCBITaxon:457429
SOURCE_ASSERTION mibig:BGC0001746 PMID:27403888

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

TaxonSourceReference
Streptomyces pristinaespiralis
NCBITaxon:38300
CHEBI PMID:27403888
Streptomyces pristinaespiralis
NCBITaxon:457429
LOTUS DOI:10.1002/ANIE.201605425

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0001746 Streptomyces pristinaespiralis ATCC 25486
NCBITaxon:457429
CLUSTER_UNSTATED genbank:NZ_CM000950.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Provenance

Source conceptSourceVersion
BGC0001746MIBIG3
CHEBI:138165CHEBI3-star

This page is generated from data/natural_products/terpenoids/2s-3r-9r-pristinol.yaml, which is generated from the committed inventories. Neither is edited by hand.