avermitilol
CHEBI:63702 EXACT SEEDED
A carbotricyclic compound that consists of decahydro-1H-1H-cyclopropa[a]naphthalene bearing four methyl substituents at position 1, 1, 3a and 7 as well as a hydroxy substituent at position 4 (the (1aR,3aS,4S,7R,7aS,7bR)-diastereomer).
Structure
| Standard InChIKey | BLGPPSRDEKNCLT-CDWXYHGHSA-N |
|---|---|
| SMILES | [H][C@@]12CC[C@]3(C)[C@@H](O)CC[C@@H](C)[C@@]3([H])[C@]1([H])C2(C)C |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA019411 |
Filing pathway
Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is terpene, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces avermitilis MA-4680 = NBRC 14893 NCBITaxon:227882 |
SOURCE_ASSERTION | mibig:BGC0000683 | PMID:20536237 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces avermitilis NCBITaxon:33903 |
LOTUS | DOI:10.1021/JA103087W |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000683 | Streptomyces avermitilis MA-4680 = NBRC 14893 NCBITaxon:227882 |
CLUSTER_UNSTATED | genbank:BA000030.3 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000683 | MIBIG | 3 |
| CHEBI:63702 | CHEBI | 3-star |
This page is generated from data/natural_products/terpenoids/avermitilol.yaml, which is generated from the committed inventories. Neither is edited by hand.