casbene

CHEBI:17695 EXACT SEEDED antifungal

A diterpene comprising bicyclo[12.1.0]pentadeca-2,6,10-triene having three methyl substituents located at the 3-, 7- and 11-positions as well as gem-dimethyl groups at the 15-position.

Structure

Standard InChIKey	ZJMVJDFTNPZVMB-QOCMWZQCSA-N
SMILES	C/C/1=C\CC/C(=C/C2C(C2(C)C)CC/C(=C/CC1)/C)/C
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	pubchem:5280437

Filing pathway

Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is terpene, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Jatropha curcas NCBITaxon:180498	SOURCE_ASSERTION	mibig:BGC0002723	DOI:10.1105/tpc.114.129668

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Ricinus communis NCBITaxon:3988	LOTUS	DOI:10.1016/0003-9861(85)90171-7
Ricinus communis NCBITaxon:3988	LOTUS	DOI:10.1104/PP.81.2.335

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0002723	Jatropha curcas NCBITaxon:180498	CLUSTER_DEMONSTRATED	genbank:GPS_020388126.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Elsewhere in the fleet

AntibioticMech — CHEBI:17695 (same structure, same inchikey)

Provenance

Source concept	Source	Version
BGC0002723	MIBIG	2
CHEBI:17695	CHEBI	3-star

This page is generated from data/natural_products/terpenoids/casbene.yaml, which is generated from the committed inventories. Neither is edited by hand.