cattleyene

naturalproductmech:mibig-49ca9fad2a MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	RNFNEBCHHXUETQ-KSOAMXKZSA-N
SMILES	C[C@@H]1CCC2=C3C[C@@]4(C)CCC(C)(C)[C@H]4[C@@H]3CC[C@]21C
Stereochemistry	fully defined
Cross-references	npatlas:NPA025669

Filing pathway

Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is terpene, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces cattleya NRRL 8057 = DSM 46488 NCBITaxon:1003195	BGC_CORRELATED	mibig:BGC0002309	PMID:21868806

Occurrences 2

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces cattleya NCBITaxon:29303	LOTUS	DOI:10.1002/ANIE.201902950
Streptomyces cattleya NCBITaxon:29303	LOTUS	DOI:10.1128/JB.05583-11

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0002309	Streptomyces cattleya NRRL 8057 = DSM 46488 NCBITaxon:1003195	CLUSTER_DEMONSTRATED	genbank:FQ859185.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Biosynthesis curated

Written by a curator with claim-level evidence on each step; not derived from a source. This is what the rest of the record exists to support.

Step	Enzyme	Reaction	Substrate → product	Evidence
1	Cattleyene synthase UniProtKB:F8JK18	RHEA:78987	CHEBI:58756 → naturalproductmech:mibig-49ca9fad2a	DOI:10.1002/anie.201902950

Step 1: Streptomyces cattleya CyS/SCATT_p16530 cyclizes (2E,6E,10E)-geranylgeranyl diphosphate to cattleyene.

Mechanism & Biosynthesis Overview

Causal graph — biosynthesis 3 nodes, 2 edges

Streptomyces cattleya cattleyene biosynthesis graph for CyS-catalyzed cyclization of (2E,6E,10E)-geranylgeranyl diphosphate to cattleyene.

Subject	Predicate	Object	Notes	Evidence
(2E,6E,10E)-geranylgeranyl diphosphate	is cyclized by	CyS		DOI:10.1002/anie.201902950 reference DOI:10.1002/anie.201902950 evidence type PRIMARY_EXPERIMENT snippet The first enzyme from Streptomyces cattleya produced the novel compound cattleyene. notes UniProtKB:F8JK18 resolves to the Streptomyces cattleya CyS/SCATT_p16530 gene product on plasmid pSCATT, maps to EMBL CP003229 protein AEW99846.1, and annotates RHEA:78987 for cyclization of (2E,6E,10E)-geranylgeranyl diphosphate to cattleyene plus diphosphate.
CyS	forms	cattleyene		DOI:10.1002/anie.201902950 reference DOI:10.1002/anie.201902950 evidence type PRIMARY_EXPERIMENT snippet The first enzyme from Streptomyces cattleya produced the novel compound cattleyene. notes UniProtKB:F8JK18 resolves to the Streptomyces cattleya CyS/SCATT_p16530 gene product on plasmid pSCATT, maps to EMBL CP003229 protein AEW99846.1, and annotates RHEA:78987 for cyclization of (2E,6E,10E)-geranylgeranyl diphosphate to cattleyene plus diphosphate.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Explore across X-Mech

AntibioticMech (cattleyene) ↗ MediaIngredientMech (naturalproductmech:mibig-49ca9fad2a) ↗ TaxonMech: Streptomyces cattleya NRRL 8057 = DSM 46488 (NCBITaxon:1003195) ↗ PathwayMech (mibig:BGC0002309) ↗

Provenance

Source concept	Source	Version
BGC0002309	MIBIG	2

This page is generated from data/natural_products/terpenoids/cattleyene.yaml, which is generated from the committed inventories. Neither is edited by hand.