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(-)-ent-quiannulatene

naturalproductmech:mibig-5ee5852d29 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.
What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKeyKZVSASHATZZHHJ-VOVQMDQVSA-N
SMILES[H][C@]12CC[C@@]3(C(C)=C4C[C@]5(CC[C@@H]([C@@]5(C[C@]4([C@]13CC[C@@H]2C)[H])[H])C(C)C)C)C
Stereochemistryfully defined
Cross-referenceslotus:Q124986207

Filing pathway

Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is terpene, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

TaxonBasisClusterEvidence
Arabidopsis thaliana
NCBITaxon:3702		 SOURCE_ASSERTION mibig:BGC0002398 DOI:10.1073/pnas.1705567114

Occurrences 0

None cited.

Biosynthetic gene clusters 1

AccessionHostLocus evidenceGenome
mibig:BGC0002398 Arabidopsis thaliana
NCBITaxon:3702 		CLUSTER_DEMONSTRATED genbank:CP002686.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Biosynthesis curated

Written by a curator with claim-level evidence on each step; not derived from a source. This is what the rest of the record exists to support.

StepEnzymeReactionSubstrate → productEvidence
1 Terpenoid synthase 25
UniProtKB:Q9LIA1		 CHEBI:16818 → naturalproductmech:mibig-5ee5852d29 DOI:10.1073/pnas.1705567114

Step 1: Arabidopsis thaliana TPS25/At3g29410 cyclizes all-trans-pentaprenyl diphosphate to (-)-ent-quiannulatene.

Mechanism & Biosynthesis Overview

PRODUCERS & OCCURRENCE 1 producer (0 causal) 0 cited occurrences BIOSYNTHETIC LOCUS 1 gene cluster 1 curated pathway step NATURAL PRODUCT (-)-ent-quiannulatene naturalproductmech:mibig-5ee5852d29 Terpenoids TARGETS & BIOACTIVITY 0 molecular targets 0 bioactivities · 1 graph

Causal graph — biosynthesis 3 nodes, 2 edges

Arabidopsis thaliana (-)-ent-quiannulatene biosynthesis graph for TPS25-catalyzed cyclization of all-trans-pentaprenyl diphosphate to (-)-ent-quiannulatene.

SubjectPredicateObjectNotesEvidence
all-trans-pentaprenyl diphosphate is cyclized by AtTPS25
DOI:10.1073/pnas.1705567114
  • reference
    DOI:10.1073/pnas.1705567114
    evidence type
    PRIMARY_EXPERIMENT
    snippet
    Transient expression of seven TPSs from A. thaliana, Capsella rubella, and Brassica oleracea in Nicotiana benthamiana yielded fungal-type sesterterpenes
    notes
    UniProtKB:Q9LIA1 resolves to the reviewed Arabidopsis thaliana TPS25/At3g29410 gene product, maps to EMBL CP002686 protein AEE77582.1, and is the terpenoid synthase in the CP002686.1 BGC0002398 interval that cyclizes all-trans-pentaprenyl diphosphate to (-)-ent-quiannulatene.
AtTPS25 forms (-)-ent-quiannulatene
DOI:10.1073/pnas.1705567114
  • reference
    DOI:10.1073/pnas.1705567114
    evidence type
    PRIMARY_EXPERIMENT
    snippet
    Transient expression of seven TPSs from A. thaliana, Capsella rubella, and Brassica oleracea in Nicotiana benthamiana yielded fungal-type sesterterpenes
    notes
    UniProtKB:Q9LIA1 resolves to the reviewed Arabidopsis thaliana TPS25/At3g29410 gene product, maps to EMBL CP002686 protein AEE77582.1, and is the terpenoid synthase in the CP002686.1 BGC0002398 interval that cyclizes all-trans-pentaprenyl diphosphate to (-)-ent-quiannulatene.

Every edge carries its own citation; an uncited edge is refused by the corpus tests.

Explore across X-Mech

AntibioticMech ((-)-ent-quiannulatene) ↗ MediaIngredientMech (naturalproductmech:mibig-5ee5852d29) ↗ TaxonMech: Arabidopsis thaliana (NCBITaxon:3702) ↗ PathwayMech (mibig:BGC0002398) ↗

Provenance

Source conceptSourceVersion
BGC0002398MIBIG2

This page is generated from data/natural_products/terpenoids/ent-quiannulatene.yaml, which is generated from the committed inventories. Neither is edited by hand.