hygromycin A
naturalproductmech:mibig-4930c38413 MINTED SEEDED
Structure
| Standard InChIKey | YQYJSBFKSSDGFO-KEHBMHOOSA-N |
|---|---|
| SMILES | CC(=O)[C@H]1O[C@@H](OC2=C(O)C=C(\C=C(/C)C(=O)N[C@@H]3[C@H](O)[C@H]4OCO[C@H]4[C@@H](O)[C@@H]3O)C=C2)[C@@H](O)[C@@H]1O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA014061, pubchem:6433481 |
Filing pathway
Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is saccharide, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces hygroscopicus NCBITaxon:1912 |
SOURCE_ASSERTION | mibig:BGC0000698 | PMID:16873023 |
| Streptomyces hygroscopicus subsp. hygroscopicus NCBITaxon:68042 |
SOURCE_ASSERTION | mibig:BGC0000699 | PMID:19362651 |
Occurrences 2
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces hygroscopicus NCBITaxon:1912 |
LOTUS | DOI:10.1016/J.CHEMBIOL.2006.05.013 |
| Streptomyces hygroscopicus NCBITaxon:1912 |
LOTUS | DOI:10.1021/JA01558A031 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000698 | Streptomyces hygroscopicus NCBITaxon:1912 |
CLUSTER_UNSTATED | genbank:DQ314862.1 |
| mibig:BGC0000699 | Streptomyces hygroscopicus subsp. hygroscopicus NCBITaxon:68042 |
CLUSTER_UNSTATED | genbank:AJ628642.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Open questions 1
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000698, BGC0000699. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000698 | MIBIG | 5 |
| BGC0000699 | MIBIG | 5 |
This page is generated from data/natural_products/terpenoids/hygromycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.