methylenomycin A
naturalproductmech:mibig-697eb70f76 MINTED SEEDED
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
Structure
| Standard InChIKey | HBECYYFDLZZMPL-WLGLDCGKSA-N |
|---|---|
| SMILES | C[C@@]12O[C@]1(C)C(=O)C(=C)[C@H]2C(O)=O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA013552 |
Filing pathway
Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces coelicolor A3(2) NCBITaxon:100226 |
SOURCE_ASSERTION | mibig:BGC0000914 | PMID:19054329 |
Occurrences 24
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces albidoflavus NCBITaxon:1886 |
LOTUS | DOI:10.1007/S10295-013-1383-2 |
| Streptomyces albidoflavus NCBITaxon:1886 |
LOTUS | DOI:10.1016/0378-1119(91)90352-C |
| Streptomyces albidoflavus NCBITaxon:1886 |
LOTUS | DOI:10.1016/0378-1119(92)90537-Y |
| Streptomyces albidoflavus NCBITaxon:1886 |
LOTUS | DOI:10.1039/B101615F |
| Streptomyces albidoflavus NCBITaxon:1886 |
LOTUS | DOI:10.1073/PNAS.0805530105 |
| Streptomyces albidoflavus NCBITaxon:1886 |
LOTUS | DOI:10.1099/00221287-95-1-96 |
| Streptomyces albidoflavus NCBITaxon:1886 |
LOTUS | DOI:10.1111/J.1365-2958.2008.06560.X |
| Streptomyces albidoflavus NCBITaxon:1886 |
LOTUS | DOI:10.1128/JB.00017-11 |
| Streptomyces albidoflavus NCBITaxon:1886 |
LOTUS | DOI:10.1128/JB.173.4.1523-1529.1991 |
| Streptomyces albidoflavus NCBITaxon:1886 |
LOTUS | DOI:10.1128/JB.179.17.5511-5515.1997 |
| Streptomyces albidoflavus NCBITaxon:1886 |
LOTUS | DOI:10.1186/S13036-017-0071-6 |
| Streptomyces coelicolor NCBITaxon:1902 |
LOTUS | DOI:10.1007/S10295-013-1383-2 |
| Streptomyces coelicolor NCBITaxon:1902 |
LOTUS | DOI:10.1016/0378-1119(91)90352-C |
| Streptomyces coelicolor NCBITaxon:1902 |
LOTUS | DOI:10.1016/0378-1119(92)90537-Y |
| Streptomyces coelicolor NCBITaxon:1902 |
LOTUS | DOI:10.1039/B101615F |
| Streptomyces coelicolor NCBITaxon:1902 |
LOTUS | DOI:10.1073/PNAS.0805530105 |
| Streptomyces coelicolor NCBITaxon:1902 |
LOTUS | DOI:10.1099/00221287-95-1-96 |
| Streptomyces coelicolor NCBITaxon:1902 |
LOTUS | DOI:10.1111/J.1365-2958.2008.06560.X |
| Streptomyces coelicolor NCBITaxon:1902 |
LOTUS | DOI:10.1128/JB.00017-11 |
| Streptomyces coelicolor NCBITaxon:1902 |
LOTUS | DOI:10.1128/JB.173.4.1523-1529.1991 |
| Streptomyces coelicolor NCBITaxon:1902 |
LOTUS | DOI:10.1128/JB.179.17.5511-5515.1997 |
| Streptomyces coelicolor NCBITaxon:1902 |
LOTUS | DOI:10.1186/S13036-017-0071-6 |
| Streptomyces violaceoruber NCBITaxon:1935 |
LOTUS | DOI:10.1111/J.1574-6968.2002.TB11290.X |
| Streptomyces violaceoruber NCBITaxon:1935 |
LOTUS | DOI:10.7164/ANTIBIOTICS.27.393 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000914 | Streptomyces coelicolor A3(2) NCBITaxon:100226 |
CLUSTER_UNSTATED | genbank:AL589148.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000914 | MIBIG | 5 |
This page is generated from data/natural_products/terpenoids/methylenomycin-a.yaml, which is generated from the committed inventories. Neither is edited by hand.