platencin

naturalproductmech:mibig-560750e959 MINTED SEEDED

Grounding review: No 3-star ChEBI entry shares this structure, so the record keeps a content-hashed identifier.

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

Structure

Standard InChIKey	DWUHGPPFFABTIY-KMVHLTCXSA-N
SMILES	C[C@@]1(C2C[C@@H]3CC[C@]2(CC3=C)C=CC1=O)CCC(=O)NC4=C(C=CC(=C4O)C(=O)O)O
Stereochemistry	undefined stereocentres — the InChIKey does not distinguish this compound from its stereoisomers
Cross-references	pubchem:44450228

Filing pathway

Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is terpene, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces platensis NCBITaxon:58346	BGC_CHARACTERIZED	mibig:BGC0001156	PMID:20232845

Occurrences 1

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces platensis NCBITaxon:58346	LOTUS	DOI:10.1021/OL100342M

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001156	Streptomyces platensis NCBITaxon:58346	CLUSTER_DEMONSTRATED	genbank:GQ398492.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Bioactivities 2

Entries preserve source qualifiers, targets and evidence. Repeated assay names or values are not independent replications; inspect source detail for differences.

Assay	Result	Target enzyme	Source detail
Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	ACTIVE	Not recorded	PMID:33229545 assay Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors evidence reference PMID:33229545 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347160, deposited by NCGC; assay type Confirmatory. call ACTIVE
qHTS for activators of Nrf2/ARE signaling pathway screened against the NCATS CANVASS Library	ACTIVE	Not recorded	PMID:30648156 assay qHTS for activators of Nrf2/ARE signaling pathway screened against the NCATS CANVASS Library evidence reference PMID:30648156 evidence type DATABASE_ASSERTION notes PubChem BioAssay AID 1347391, deposited by NCGC; assay type Confirmatory. call ACTIVE

Explore across X-Mech

AntibioticMech (platencin) ↗ MediaIngredientMech (naturalproductmech:mibig-560750e959) ↗ TaxonMech: Streptomyces platensis (NCBITaxon:58346) ↗ PathwayMech (mibig:BGC0001156) ↗

Provenance

Source concept	Source	Version
BGC0001156	MIBIG	5

This page is generated from data/natural_products/terpenoids/platencin-2.yaml, which is generated from the committed inventories. Neither is edited by hand.