platencin
CHEBI:68241 EXACT SEEDED antibacterial
What these status tags mean
Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.
Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.
A monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the polycyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase.
Structure
| Standard InChIKey | DWUHGPPFFABTIY-RLWZQHMASA-N |
|---|---|
| SMILES | [H][C@@]12C[C@@H]3CC[C@]1(CC3=C)C=CC(=O)[C@@]2(C)CCC(=O)NC1=C(O)C(=CC=C1O)C(O)=O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:44450228, npatlas:NPA012954 |
Filing pathway
Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is terpene, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces platensis NCBITaxon:58346 |
BGC_CHARACTERIZED | mibig:BGC0001140 | PMID:17456595 |
Occurrences 4
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1016/J.BMC.2010.02.030 |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1016/J.BMCL.2009.06.061 |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1021/NP100635F |
| Streptomyces platensis NCBITaxon:58346 |
CHEBI | PMID:21214253 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001140 | Streptomyces platensis NCBITaxon:58346 |
CLUSTER_DEMONSTRATED | genbank:FJ655920.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Mechanism & Biosynthesis Overview
Elsewhere in the fleet
- AntibioticMech — CHEBI:68241 (same structure, same inchikey)
Explore across X-Mech
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001140 | MIBIG | 5 |
| CHEBI:68241 | CHEBI | 3-star |
This page is generated from data/natural_products/terpenoids/platencin.yaml, which is generated from the committed inventories. Neither is edited by hand.