platensimycin
CHEBI:68236 EXACT SEEDED antibacterial
A monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the oxatetracyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase.
Structure
| Standard InChIKey | CSOMAHTTWTVBFL-OFBLZTNGSA-N |
|---|---|
| SMILES | [H][C@]12C[C@]3([H])O[C@@]1(C)C[C@@]1(C2)C=CC(=O)[C@@](C)(CCC(=O)NC2=C(O)C=CC(C(O)=O)=C2O)[C@]31[H] |
| Stereochemistry | fully defined |
| Cross-references | pubchem:6857724, npatlas:NPA017180 |
Filing pathway
Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is terpene, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces platensis NCBITaxon:58346 |
BGC_CHARACTERIZED | mibig:BGC0001140 | PMID:16710421 |
Occurrences 14
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1007/S00253-009-2428-3 |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1007/S00253-013-5201-6 |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1007/S10295-016-1769-Z |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1016/J.BMC.2016.04.026 |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1016/J.BMCL.2009.06.061 |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1021/JA062232P |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1021/NP100635F |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1021/OL062041R |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1021/OL800251V |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1038/JA.2012.97 |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1038/JA.2017.49 |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1039/B810113B |
| Streptomyces platensis NCBITaxon:58346 |
LOTUS | DOI:10.1128/AAC.01358-08 |
| Streptomyces platensis NCBITaxon:58346 |
CHEBI | PMID:21214253 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001140 | Streptomyces platensis NCBITaxon:58346 |
CLUSTER_DEMONSTRATED | genbank:FJ655920.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:68236 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001140 | MIBIG | 5 |
| CHEBI:68236 | CHEBI | 3-star |
This page is generated from data/natural_products/terpenoids/platensimycin.yaml, which is generated from the committed inventories. Neither is edited by hand.